Pregnancy lactating women Severe liver failure (Child-pugh C) or liver enzymes more than 3 times normal Renal failure (glomerular filtration less than 30 ml / min) Chronic use of immunosuppressive drugs or corticosteroids Absolute lymphocyte count less than 500 per cubic millimeter Absolute neutrophil counts less than 1000 per cubic millimeter

Pregnancy lactating women Severe liver failure (Child-pugh C) or liver enzymes more than 3 times normal Renal failure (glomerular filtration less than 30 ml / min) Chronic use of immunosuppressive drugs or corticosteroids Absolute lymphocyte count less than 500 per cubic millimeter Absolute neutrophil counts less than 1000 per cubic millimeter