Severe liver disease (Child Pugh score ≥ C, AST>10 times upper limit) Pregnancy Breastfeeding Sever renal failure ( estimated glomerular filtration rate ≤30 mL/min/1.73 m2) or receiving dialysis Drug interactions (Methimazole, chloroquine, hydroxychloroquine)

Severe liver disease (Child Pugh score ≥ C, AST>10 times upper limit) Pregnancy Breastfeeding Sever renal failure ( estimated glomerular filtration rate ≤30 mL/min/1.73 m2) or receiving dialysis Drug interactions (Methimazole, chloroquine, hydroxychloroquine)