History of allergy to dimethyl fumarate Use of dimethyl fumarate before current hospitalization Patients more than 70 years of age with a history of any of the following in the last six months: Class III / IV Heart Failure Based on the New York Heart Association (NYHA) classification, Insulin-dependent diabetes, Angina pectoris, Malignancy Uncontrolled bacterial, fungal, or viral infection (other than COVID-19). Any history of receiving convalescent plasma therapy Absolute neutrophil count (ANC) < 500 Platelets count < 50,000 Pregnant women or those intending to become pregnant Breastfeeding women AST or ALT > 5 times the upper limits of normal (ULN) Estimated glomerular filtration rate (eGFR) < 30 ml/min in 1.73 m2 using MDRD equation

History of allergy to dimethyl fumarate Use of dimethyl fumarate before current hospitalization Patients more than 70 years of age with a history of any of the following in the last six months: Class III / IV Heart Failure Based on the New York Heart Association (NYHA) classification, Insulin-dependent diabetes, Angina pectoris, Malignancy Uncontrolled bacterial, fungal, or viral infection (other than COVID-19). Any history of receiving convalescent plasma therapy Absolute neutrophil count (ANC) < 500 Platelets count < 50,000 Pregnant women or those intending to become pregnant Breastfeeding women AST or ALT > 5 times the upper limits of normal (ULN) Estimated glomerular filtration rate (eGFR) < 30 ml/min in 1.73 m2 using MDRD equation