Allergy to Tocilizumab or one of the components of drug formulations. ANC < 500 cells/mm Pelatelet < 50000 cells/mm Hepatic transaminases > 5 times normal range or mild increase in liver transaminases associated with signs and symptoms of liver disorder History of malignancy Diverticulitis Positive procalcitonin and active infection (including latent or active tuberculosis infection) Taking other rheumatoid drugs at the same time

Allergy to Tocilizumab or one of the components of drug formulations. ANC < 500 cells/mm Pelatelet < 50000 cells/mm Hepatic transaminases > 5 times normal range or mild increase in liver transaminases associated with signs and symptoms of liver disorder History of malignancy Diverticulitis Positive procalcitonin and active infection (including latent or active tuberculosis infection) Taking other rheumatoid drugs at the same time