The end stage renal disease people or GFR<60 The people with liver disease Intubate or end stage disease people The people with consumption vitamin A supplement The patients that suffering cancer disease or chemo-radio therapy The hemodialysis patient GFR<20 The people infected to bacterial or fungal disease

The end stage renal disease people or GFR<60 The people with liver disease Intubate or end stage disease people The people with consumption vitamin A supplement The patients that suffering cancer disease or chemo-radio therapy The hemodialysis patient GFR<20 The people infected to bacterial or fungal disease