1. alt/ast \>5 times the upper limit of normal. 2. stage v ckd (i.e. egfr \<15 ml/min/1.73 m2 or requiring dialysis). 3. pregnant or breast feeding. 4. severe co-morbidity (e.g. uncontrolled hypertension and uncontrolled dm, systemic disease which affect the vital organs severity, immunocompromised patients etc.) as per investigator's assessment. 5. comorbid condition like myocardial infarction or heart failure within 90 days of recruitment. 6. prolong qt interval (\>450 ms). 7. patients on invasive mechanical ventilation.

1. alt/ast \>5 times the upper limit of normal. 2. stage v ckd (i.e. egfr \<15 ml/min/1.73 m2 or requiring dialysis). 3. pregnant or breast feeding. 4. severe co-morbidity (e.g. uncontrolled hypertension and uncontrolled dm, systemic disease which affect the vital organs severity, immunocompromised patients etc.) as per investigator's assessment. 5. comorbid condition like myocardial infarction or heart failure within 90 days of recruitment. 6. prolong qt interval (\>450 ms). 7. patients on invasive mechanical ventilation.

alt/ast >5 times the upper limit of normal. stage v ckd (i.e. egfr <15 ml/min/1.73 m2 or requiring dialysis). pregnant or breast feeding. severe co-morbidity (e.g. uncontrolled hypertension and uncontrolled dm, systemic disease which affect the vital organs severity, immunocompromised patients etc.) as per investigator's assessment. comorbid condition like myocardial infarction or heart failure within 90 days of recruitment. prolong qt interval (>450 ms). patients on invasive mechanical ventilation.

alt/ast >5 times the upper limit of normal. stage v ckd (i.e. egfr <15 ml/min/1.73 m2 or requiring dialysis). pregnant or breast feeding. severe co-morbidity (e.g. uncontrolled hypertension and uncontrolled dm, systemic disease which affect the vital organs severity, immunocompromised patients etc.) as per investigator's assessment. comorbid condition like myocardial infarction or heart failure within 90 days of recruitment. prolong qt interval (>450 ms). patients on invasive mechanical ventilation.

1. alt/ast >5 times the upper limit of normal. 2. stage v ckd (i.e. egfr <15 ml/min/1.73 m2 or requiring dialysis). 3. pregnant or breast feeding. 4. severe co-morbidity (e.g. uncontrolled hypertension and uncontrolled dm, systemic disease which affect the vital organs severity, immunocompromised patients etc.) as per investigator's assessment. 5. comorbid condition like myocardial infarction or heart failure within 90 days of recruitment. 6. prolong qt interval (>450 ms). 7. patients on invasive mechanical ventilation.

1. alt/ast >5 times the upper limit of normal. 2. stage v ckd (i.e. egfr <15 ml/min/1.73 m2 or requiring dialysis). 3. pregnant or breast feeding. 4. severe co-morbidity (e.g. uncontrolled hypertension and uncontrolled dm, systemic disease which affect the vital organs severity, immunocompromised patients etc.) as per investigator's assessment. 5. comorbid condition like myocardial infarction or heart failure within 90 days of recruitment. 6. prolong qt interval (>450 ms). 7. patients on invasive mechanical ventilation.