1. subjects with symptoms of suspected covid-19 infection (respiratory symptoms, headache, malaise, olfactory disorders, taste disorders, etc.) 2. subjects with a history of covid-19 (hearing from subjects) 3. subjects who have participated in unapproved vaccine clinical trials 4. subjects with axillary temperature of 37.0 degree or higher 5. subjects who have a history of anaphylaxis 6. subjects who have serious renal, liquid, respiratory, liver, kidney, digestive, and neuropsychiatric history has a current medical history 7. subjects with a history of convulsion or epilepsy 8. subjects with a history of diagnosis of immunodeficiency 9. subjects who have a close relative (within 3rd degree) of congenital immunodeficiency 10. subjects who have a history of bronchial asthma 11. subjects who had a fever of 39.0°c or higher within 2 days after the last vaccination, and those who suspected allergy such as a systemic rash 12. females who wish to become pregnant from the date of study registration to 12 weeks after the first inoculation of the investigational drug, and pregnant females who are breast-feeding. in addition, females who may become pregnant and their male sexual partners should use appropriate contraceptives (pill), condoms, vasectomy, tubal ligation, diaphragm, intrauterine devices, spermicides, intrauterine hormone-releasing system, etc. from the study entry date until 12 weeks after vaccination 13. subjects who have participated in clinical trials of other unapproved drugs and received the investigational drug within 4 weeks before the start of this clinical trial (starting from vaccination day) 14. subjects who have been received a live vaccine, inactivated vaccine, or toxoid within 4 weeks before the start of this clinical trial (starting from vaccination day) 15. subjects who have been administered with drugs that affect the immune system (excluding external preparations) such as immunomodulators (dmards, etc.), immunosuppressants, biologics, etc. within 4 weeks from vaccination 16. subjects who received blood transfusion or gamma globulin therapy within 12 week before vaccination, or high-dose gamma globulin therapy (200 mg/kg or more) within 24 weeks before vaccination 17. subjects who have a history of overseas travel within 4 weeks before the start of the clinical trial (starting from vaccination day) 18. subjects who are unable to comply with the clinical trial protocol and follow up (for mental, family, social or geographical reasons) 19. subjects who are judged to be ineligible for this clinical trial by the investigator

1. subjects with symptoms of suspected covid-19 infection (respiratory symptoms, headache, malaise, olfactory disorders, taste disorders, etc.) 2. subjects with a history of covid-19 (hearing from subjects) 3. subjects who have participated in unapproved vaccine clinical trials 4. subjects with axillary temperature of 37.0 degree or higher 5. subjects who have a history of anaphylaxis 6. subjects who have serious renal, liquid, respiratory, liver, kidney, digestive, and neuropsychiatric history has a current medical history 7. subjects with a history of convulsion or epilepsy 8. subjects with a history of diagnosis of immunodeficiency 9. subjects who have a close relative (within 3rd degree) of congenital immunodeficiency 10. subjects who have a history of bronchial asthma 11. subjects who had a fever of 39.0°c or higher within 2 days after the last vaccination, and those who suspected allergy such as a systemic rash 12. females who wish to become pregnant from the date of study registration to 12 weeks after the first inoculation of the investigational drug, and pregnant females who are breast-feeding. in addition, females who may become pregnant and their male sexual partners should use appropriate contraceptives (pill), condoms, vasectomy, tubal ligation, diaphragm, intrauterine devices, spermicides, intrauterine hormone-releasing system, etc. from the study entry date until 12 weeks after vaccination 13. subjects who have participated in clinical trials of other unapproved drugs and received the investigational drug within 4 weeks before the start of this clinical trial (starting from vaccination day) 14. subjects who have been received a live vaccine, inactivated vaccine, or toxoid within 4 weeks before the start of this clinical trial (starting from vaccination day) 15. subjects who have been administered with drugs that affect the immune system (excluding external preparations) such as immunomodulators (dmards, etc.), immunosuppressants, biologics, etc. within 4 weeks from vaccination 16. subjects who received blood transfusion or gamma globulin therapy within 12 week before vaccination, or high-dose gamma globulin therapy (200 mg/kg or more) within 24 weeks before vaccination 17. subjects who have a history of overseas travel within 4 weeks before the start of the clinical trial (starting from vaccination day) 18. subjects who are unable to comply with the clinical trial protocol and follow up (for mental, family, social or geographical reasons) 19. subjects who are judged to be ineligible for this clinical trial by the investigator

subjects with symptoms of suspected covid-19 infection (respiratory symptoms, headache, malaise, olfactory disorders, taste disorders, etc.) subjects with a history of covid-19 (hearing from subjects) subjects who have participated in unapproved vaccine clinical trials subjects with axillary temperature of 37.0 degree or higher subjects who have a history of anaphylaxis subjects who have serious renal, liquid, respiratory, liver, kidney, digestive, and neuropsychiatric history has a current medical history subjects with a history of convulsion or epilepsy subjects with a history of diagnosis of immunodeficiency subjects who have a close relative (within 3rd degree) of congenital immunodeficiency subjects who have a history of bronchial asthma subjects who had a fever of 39.0°c or higher within 2 days after the last vaccination, and those who suspected allergy such as a systemic rash females who wish to become pregnant from the date of study registration to 12 weeks after the first inoculation of the investigational drug, and pregnant females who are breast-feeding. in addition, females who may become pregnant and their male sexual partners should use appropriate contraceptives (pill), condoms, vasectomy, tubal ligation, diaphragm, intrauterine devices, spermicides, intrauterine hormone-releasing system, etc. from the study entry date until 12 weeks after vaccination subjects who have participated in clinical trials of other unapproved drugs and received the investigational drug within 4 weeks before the start of this clinical trial (starting from vaccination day) subjects who have been received a live vaccine, inactivated vaccine, or toxoid within 4 weeks before the start of this clinical trial (starting from vaccination day) subjects who have been administered with drugs that affect the immune system (excluding external preparations) such as immunomodulators (dmards, etc.), immunosuppressants, biologics, etc. within 4 weeks from vaccination subjects who received blood transfusion or gamma globulin therapy within 12 week before vaccination, or high-dose gamma globulin therapy (200 mg/kg or more) within 24 weeks before vaccination subjects who have a history of overseas travel within 4 weeks before the start of the clinical trial (starting from vaccination day) subjects who are unable to comply with the clinical trial protocol and follow up (for mental, family, social or geographical reasons) subjects who are judged to be ineligible for this clinical trial by the investigator

subjects with symptoms of suspected covid-19 infection (respiratory symptoms, headache, malaise, olfactory disorders, taste disorders, etc.) subjects with a history of covid-19 (hearing from subjects) subjects who have participated in unapproved vaccine clinical trials subjects with axillary temperature of 37.0 degree or higher subjects who have a history of anaphylaxis subjects who have serious renal, liquid, respiratory, liver, kidney, digestive, and neuropsychiatric history has a current medical history subjects with a history of convulsion or epilepsy subjects with a history of diagnosis of immunodeficiency subjects who have a close relative (within 3rd degree) of congenital immunodeficiency subjects who have a history of bronchial asthma subjects who had a fever of 39.0°c or higher within 2 days after the last vaccination, and those who suspected allergy such as a systemic rash females who wish to become pregnant from the date of study registration to 12 weeks after the first inoculation of the investigational drug, and pregnant females who are breast-feeding. in addition, females who may become pregnant and their male sexual partners should use appropriate contraceptives (pill), condoms, vasectomy, tubal ligation, diaphragm, intrauterine devices, spermicides, intrauterine hormone-releasing system, etc. from the study entry date until 12 weeks after vaccination subjects who have participated in clinical trials of other unapproved drugs and received the investigational drug within 4 weeks before the start of this clinical trial (starting from vaccination day) subjects who have been received a live vaccine, inactivated vaccine, or toxoid within 4 weeks before the start of this clinical trial (starting from vaccination day) subjects who have been administered with drugs that affect the immune system (excluding external preparations) such as immunomodulators (dmards, etc.), immunosuppressants, biologics, etc. within 4 weeks from vaccination subjects who received blood transfusion or gamma globulin therapy within 12 week before vaccination, or high-dose gamma globulin therapy (200 mg/kg or more) within 24 weeks before vaccination subjects who have a history of overseas travel within 4 weeks before the start of the clinical trial (starting from vaccination day) subjects who are unable to comply with the clinical trial protocol and follow up (for mental, family, social or geographical reasons) subjects who are judged to be ineligible for this clinical trial by the investigator

1. subjects with symptoms of suspected covid-19 infection (respiratory symptoms, headache, malaise, olfactory disorders, taste disorders, etc.) 2. subjects with a history of covid-19 (hearing from subjects) 3. subjects who have participated in unapproved vaccine clinical trials 4. subjects with axillary temperature of 37.0 degree or higher 5. subjects who have a history of anaphylaxis 6. subjects who have serious renal, liquid, respiratory, liver, kidney, digestive, and neuropsychiatric history has a current medical history 7. subjects with a history of convulsion or epilepsy 8. subjects with a history of diagnosis of immunodeficiency 9. subjects who have a close relative (within 3rd degree) of congenital immunodeficiency 10. subjects who have a history of bronchial asthma 11. subjects who had a fever of 39.0°c or higher within 2 days after the last vaccination, and those who suspected allergy such as a systemic rash 12. females who wish to become pregnant from the date of study registration to 12 weeks after the first inoculation of the investigational drug, and pregnant females who are breast-feeding. in addition, females who may become pregnant and their male sexual partners should use appropriate contraceptives (pill), condoms, vasectomy, tubal ligation, diaphragm, intrauterine devices, spermicides, intrauterine hormone-releasing system, etc. from the study entry date until 12 weeks after vaccination 13. subjects who have participated in clinical trials of other unapproved drugs and received the investigational drug within 4 weeks before the start of this clinical trial (starting from vaccination day) 14. subjects who have been received a live vaccine, inactivated vaccine, or toxoid within 4 weeks before the start of this clinical trial (starting from vaccination day) 15. subjects who have been administered with drugs that affect the immune system (excluding external preparations) such as immunomodulators (dmards, etc.), immunosuppressants, biologics, etc. within 4 weeks from vaccination 16. subjects who received blood transfusion or gamma globulin therapy within 12 week before vaccination, or high-dose gamma globulin therapy (200 mg/kg or more) within 24 weeks before vaccination 17. subjects who have a history of overseas travel within 4 weeks before the start of the clinical trial (starting from vaccination day) 18. subjects who are unable to comply with the clinical trial protocol and follow up (for mental, family, social or geographical reasons) 19. subjects who are judged to be ineligible for this clinical trial by the investigator

1. subjects with symptoms of suspected covid-19 infection (respiratory symptoms, headache, malaise, olfactory disorders, taste disorders, etc.) 2. subjects with a history of covid-19 (hearing from subjects) 3. subjects who have participated in unapproved vaccine clinical trials 4. subjects with axillary temperature of 37.0 degree or higher 5. subjects who have a history of anaphylaxis 6. subjects who have serious renal, liquid, respiratory, liver, kidney, digestive, and neuropsychiatric history has a current medical history 7. subjects with a history of convulsion or epilepsy 8. subjects with a history of diagnosis of immunodeficiency 9. subjects who have a close relative (within 3rd degree) of congenital immunodeficiency 10. subjects who have a history of bronchial asthma 11. subjects who had a fever of 39.0°c or higher within 2 days after the last vaccination, and those who suspected allergy such as a systemic rash 12. females who wish to become pregnant from the date of study registration to 12 weeks after the first inoculation of the investigational drug, and pregnant females who are breast-feeding. in addition, females who may become pregnant and their male sexual partners should use appropriate contraceptives (pill), condoms, vasectomy, tubal ligation, diaphragm, intrauterine devices, spermicides, intrauterine hormone-releasing system, etc. from the study entry date until 12 weeks after vaccination 13. subjects who have participated in clinical trials of other unapproved drugs and received the investigational drug within 4 weeks before the start of this clinical trial (starting from vaccination day) 14. subjects who have been received a live vaccine, inactivated vaccine, or toxoid within 4 weeks before the start of this clinical trial (starting from vaccination day) 15. subjects who have been administered with drugs that affect the immune system (excluding external preparations) such as immunomodulators (dmards, etc.), immunosuppressants, biologics, etc. within 4 weeks from vaccination 16. subjects who received blood transfusion or gamma globulin therapy within 12 week before vaccination, or high-dose gamma globulin therapy (200 mg/kg or more) within 24 weeks before vaccination 17. subjects who have a history of overseas travel within 4 weeks before the start of the clinical trial (starting from vaccination day) 18. subjects who are unable to comply with the clinical trial protocol and follow up (for mental, family, social or geographical reasons) 19. subjects who are judged to be ineligible for this clinical trial by the investigator