Aged 40-65 years Voluntarily participate in this clinical trial and sign off "informed consent form" Chest imaging confirm COVID-19 featured lesions in the lung The SARS-CoV-2 nucleic acid test was positive Diagnosed with severe pneumonia of COVID-19: respiratory distress, Respiratory rate (RR) ≥ 30 times/min; resting oxygen saturation of 90% or less; arterial pressure of oxygen/the fraction of inspired oxygen≤ 300 mmHg; pulmonary imaging of focus within 24-48 hours > 50% progression Patients with a diagnosis of moderate pneumonia caused by Covid-19: 1- Presence of respiratory symptoms (including shortness of breath, feeling of pain and pressure in the chest, ...) with or without fever equal to / greater than 38 ° C 2- Percentage of blood oxygen saturation in Room air at rest between 90 to 93% 3-Pulmonary infiltration less than 50%

Aged 40-65 years Voluntarily participate in this clinical trial and sign off "informed consent form" Chest imaging confirm COVID-19 featured lesions in the lung The SARS-CoV-2 nucleic acid test was positive Diagnosed with severe pneumonia of COVID-19: respiratory distress, Respiratory rate (RR) ≥ 30 times/min; resting oxygen saturation of 90% or less; arterial pressure of oxygen/the fraction of inspired oxygen≤ 300 mmHg; pulmonary imaging of focus within 24-48 hours > 50% progression Patients with a diagnosis of moderate pneumonia caused by Covid-19: 1- Presence of respiratory symptoms (including shortness of breath, feeling of pain and pressure in the chest, ...) with or without fever equal to / greater than 38 ° C 2- Percentage of blood oxygen saturation in Room air at rest between 90 to 93% 3-Pulmonary infiltration less than 50%