Patients with shock or hemodynamic instability (increase or decrease in blood pressure and irregular heartbeat) GFR less than 30 ml/minute History of cirrhosis, hepatitis and severe liver diseases History of hypertension, depression (taking fluvoxamine and other potent CYP1A2 inhibitors) and epilepsy Patients with a history of allergic reaction or allergy to melatonin Patients receiving chemotherapy for cancer Severe diseases of the immune system Pregnant and lactating women Use of alcohol and benzodiazepines

Patients with shock or hemodynamic instability (increase or decrease in blood pressure and irregular heartbeat) GFR less than 30 ml/minute History of cirrhosis, hepatitis and severe liver diseases History of hypertension, depression (taking fluvoxamine and other potent CYP1A2 inhibitors) and epilepsy Patients with a history of allergic reaction or allergy to melatonin Patients receiving chemotherapy for cancer Severe diseases of the immune system Pregnant and lactating women Use of alcohol and benzodiazepines