Active peptic ulcer Pregnancy and lactation History of colchicine or pentoxifylline allergy Concomitant use of protease inhibitors, strong inhibitors or inducers of CYP3A4 or pgp drugs, statin other than rosuvastatin Occurrence of side effects Fauvism History of alcohol use Retinopathy Neuromuscular disease Severe renal failure and GFR less than 30 ml/min Severe hepatic impairment (bilirubin higher than 2 mg/dL and albumin less than 2.8 g/dL) Active bleeding including intracerebral hemorrhage or retinal hemorrhage Chronic diarrhea or malabsorption History of heart disease (heart failure, ventricular arrhythmia, right or left heart block, QTc more than 480 milliseconds) Dissatisfaction with the company

Active peptic ulcer Pregnancy and lactation History of colchicine or pentoxifylline allergy Concomitant use of protease inhibitors, strong inhibitors or inducers of CYP3A4 or pgp drugs, statin other than rosuvastatin Occurrence of side effects Fauvism History of alcohol use Retinopathy Neuromuscular disease Severe renal failure and GFR less than 30 ml/min Severe hepatic impairment (bilirubin higher than 2 mg/dL and albumin less than 2.8 g/dL) Active bleeding including intracerebral hemorrhage or retinal hemorrhage Chronic diarrhea or malabsorption History of heart disease (heart failure, ventricular arrhythmia, right or left heart block, QTc more than 480 milliseconds) Dissatisfaction with the company