Having Iranian citizenship; Able to read and write preferably having Diploma; Adults aged 18 - 70 years; Body mass index 17 to 35kg/m2; Having sublingual temperature less than or equal to 37.2 ° C in the morning based on electronic thermometer; Negative IgG and IgM antibody titers for COVID-19 N antigen; Negative RT-PCR test forCOVID-19; Negative IgG ELISA for HIV; Having heart rate between 60 and 100; Signed the informed consent form; The participant agrees to reduce the risk of developing ofCOVID-19; For females of childbearing age 18 to 49years: not being pregnant based on the first day of the last menstrual period; For females of childbearing age 18to 49 years: negative pregnancy test based on bHCG on the day of screening and the day of vaccination if deemed necessary by principle investigator; For females of childbearing age 18 to 49 years: use at least one effective method of contraception (condoms, oral contraceptive pills, intrauterine device, Norplant capsule) and willing to continue using it up to three month after last vaccine dose; Unwillingness to have children and use effective methods of contraception up to three months after completion of vaccination (all participants). Confirmation by a psychiatrist that the participant's mental health and capacity allows him/her to make a decision regarding his/her participation in the trial.

Having Iranian citizenship; Able to read and write preferably having Diploma; Adults aged 18 - 70 years; Body mass index 17 to 35kg/m2; Having sublingual temperature less than or equal to 37.2 ° C in the morning based on electronic thermometer; Negative IgG and IgM antibody titers for COVID-19 N antigen; Negative RT-PCR test forCOVID-19; Negative IgG ELISA for HIV; Having heart rate between 60 and 100; Signed the informed consent form; The participant agrees to reduce the risk of developing ofCOVID-19; For females of childbearing age 18 to 49years: not being pregnant based on the first day of the last menstrual period; For females of childbearing age 18to 49 years: negative pregnancy test based on bHCG on the day of screening and the day of vaccination if deemed necessary by principle investigator; For females of childbearing age 18 to 49 years: use at least one effective method of contraception (condoms, oral contraceptive pills, intrauterine device, Norplant capsule) and willing to continue using it up to three month after last vaccine dose; Unwillingness to have children and use effective methods of contraception up to three months after completion of vaccination (all participants). Confirmation by a psychiatrist that the participant's mental health and capacity allows him/her to make a decision regarding his/her participation in the trial.