Lack of informed consent Lack of patient cooperation Having pulmonary embolism or intravascular thrombosis Having another active infection Having diverticulitis and gastric ulcer Having tuberculosis or hepatitis B or active hepatitis C or HIV Any major drug interaction between routine patient's drugs with any of the study drugs Pregnancy and lactation Simultaneous presence in other research study

Lack of informed consent Lack of patient cooperation Having pulmonary embolism or intravascular thrombosis Having another active infection Having diverticulitis and gastric ulcer Having tuberculosis or hepatitis B or active hepatitis C or HIV Any major drug interaction between routine patient's drugs with any of the study drugs Pregnancy and lactation Simultaneous presence in other research study