Iranian citizenship, and residing at a distance of 40-50 km from the study center The ability of participants to study and understand informed consent, preferably educational level of high school and higher Age between 18 and 55 years Body mass index between 18 and 35 kg/m2 Being healthy based on clinical and laboratory examinations Temperature less than or equal to 37.2°C sublingually measured by an electronic thermometer Negative IgG and IgM antibody titers against COVID-19 N antigen Negative RT-PCR test for COVID-19 Negative ELISA test for anti-HIV IgG Heart rate between 60 and 100 Systolic blood pressure between 90 and 140 mm Hg, diastolic blood pressure between 60 and 90 mm Hg Signing informed consent Accepting commitments to reduce the risk of COVID-19 infection in daily life Not pregnant Negative β-hCG pregnancy test on the screening and vaccination days The use of at least one safe method of contraception (condoms, oral contraceptive pills, IUD, Norplant capsule) for women of reproductive age 18 to 49 years Willingness to continue using at least one safe method of contraception (condoms, oral contraceptive pills, IUD, Norplant capsule) for women of reproductive age 18 to 49 years up to three months after the second vaccine dose Participants in the clinical trial should refrain from donating blood or plasma from the time of the first vaccine dose until three months after the second vaccine dose should not participate in another trial during the study period Expressing readiness to remain in the study for the entire study period Married men should use safe methods of contraception up to three months after the second vaccine dose

Iranian citizenship, and residing at a distance of 40-50 km from the study center The ability of participants to study and understand informed consent, preferably educational level of high school and higher Age between 18 and 55 years Body mass index between 18 and 35 kg/m2 Being healthy based on clinical and laboratory examinations Temperature less than or equal to 37.2°C sublingually measured by an electronic thermometer Negative IgG and IgM antibody titers against COVID-19 N antigen Negative RT-PCR test for COVID-19 Negative ELISA test for anti-HIV IgG Heart rate between 60 and 100 Systolic blood pressure between 90 and 140 mm Hg, diastolic blood pressure between 60 and 90 mm Hg Signing informed consent Accepting commitments to reduce the risk of COVID-19 infection in daily life Not pregnant Negative β-hCG pregnancy test on the screening and vaccination days The use of at least one safe method of contraception (condoms, oral contraceptive pills, IUD, Norplant capsule) for women of reproductive age 18 to 49 years Willingness to continue using at least one safe method of contraception (condoms, oral contraceptive pills, IUD, Norplant capsule) for women of reproductive age 18 to 49 years up to three months after the second vaccine dose Participants in the clinical trial should refrain from donating blood or plasma from the time of the first vaccine dose until three months after the second vaccine dose should not participate in another trial during the study period Expressing readiness to remain in the study for the entire study period Married men should use safe methods of contraception up to three months after the second vaccine dose

Iranian citizenship, and residence at a distance of 40-50 km from the study setting The ability of participants to study and understand informed consent, preferably educational level of high school and higher Ages 18 to 55 years Body mass index between 18 and 35 kg/m2 Complete health based on clinical and laboratory conditions Temperature less than or equal to 37.2°C sublingually based on electronic thermometer Negative IgG and IgM antibody titers against COVID-19 N antigen Negative RT-PCR test to detect COVID-19 Negative ELISA test for anti-HIV IgG Heart rate between 60 and 100 Systolic blood pressure between 90 and 140 mm Hg, diastolic blood pressure between 60 and 90 mm Hg Signing informed consent Accepting commitments to reduce the risk of COVID-19 infection No pregnancy Negative pregnancy test for β-hCG on the day of screening and the day of vaccination The use of at least one safe method of contraception (condoms, oral contraceptive pills, IUD, Norplant capsule) for women of reproductive age 18 to 49 years Willingness to continue using at least one safe method of contraception (condoms, oral contraceptive pills, IUD, Norplant capsule) for women of reproductive age 18 to 49 years up to three months after completion of the vaccination period Participants in the clinical trial should refrain from donating blood or plasma from the time of the first vaccination until three months after the last vaccination. Failure to participate in another trial during the present study Expressing the readiness of the person to remain among the people monitored in the study for the entire study period until the end of the research process within 14 months The use of one of the safest methods of contraception by married men up to three months after the last dose of vaccine

Iranian citizenship, and residence at a distance of 40-50 km from the study setting The ability of participants to study and understand informed consent, preferably educational level of high school and higher Ages 18 to 55 years Body mass index between 18 and 35 kg/m2 Complete health based on clinical and laboratory conditions Temperature less than or equal to 37.2°C sublingually based on electronic thermometer Negative IgG and IgM antibody titers against COVID-19 N antigen Negative RT-PCR test to detect COVID-19 Negative ELISA test for anti-HIV IgG Heart rate between 60 and 100 Systolic blood pressure between 90 and 140 mm Hg, diastolic blood pressure between 60 and 90 mm Hg Signing informed consent Accepting commitments to reduce the risk of COVID-19 infection No pregnancy Negative pregnancy test for β-hCG on the day of screening and the day of vaccination The use of at least one safe method of contraception (condoms, oral contraceptive pills, IUD, Norplant capsule) for women of reproductive age 18 to 49 years Willingness to continue using at least one safe method of contraception (condoms, oral contraceptive pills, IUD, Norplant capsule) for women of reproductive age 18 to 49 years up to three months after completion of the vaccination period Participants in the clinical trial should refrain from donating blood or plasma from the time of the first vaccination until three months after the last vaccination. Failure to participate in another trial during the present study Expressing the readiness of the person to remain among the people monitored in the study for the entire study period until the end of the research process within 14 months The use of one of the safest methods of contraception by married men up to three months after the last dose of vaccine

Age 18 to 55 years Body mass index between 18 and 35 kg per square meter Having complete health based on clinical and laboratory criteria No current or previous COVID-19 disease No pregnancy Useing safe methods of contraception Signing the informed consent form Having Iranian citizenship Participants should be able to read and understand informed consent, preferably with a diploma or higher certificate Temperatures less than or equal to 37.2 ° C sublingually measured by an electronic thermometer Negative IgG and IgM antibody titers against COVID-19 N antigen Negative RT-PCR -test for SARS-CoV-2 IgG ELISA negative blood test against HIV Heart rate between 60 and 100 Systolic blood pressure (between 90 and 140 mm Hg), diastolic blood pressure (between 60 and 90 mm Hg) Accept commitments to reduce the risk of COVID-19 Negative pregnancy test for β-hCG on the day of screening and the day of vaccination Clinical trial participants should refrain from donating blood or plasma from the first vaccination until 3 months after the last vaccination. Participants should not enter any other trial while in this study Expressing a person's readiness to remain among the people monitored in the study for the entire study period until the research process is completed within 14 months Use one of a safe method of contraception in men and women up to 3 months after the last dose of the vaccine

Age 18 to 55 years Body mass index between 18 and 35 kg per square meter Having complete health based on clinical and laboratory criteria No current or previous COVID-19 disease No pregnancy Useing safe methods of contraception Signing the informed consent form Having Iranian citizenship Participants should be able to read and understand informed consent, preferably with a diploma or higher certificate Temperatures less than or equal to 37.2 ° C sublingually measured by an electronic thermometer Negative IgG and IgM antibody titers against COVID-19 N antigen Negative RT-PCR -test for SARS-CoV-2 IgG ELISA negative blood test against HIV Heart rate between 60 and 100 Systolic blood pressure (between 90 and 140 mm Hg), diastolic blood pressure (between 60 and 90 mm Hg) Accept commitments to reduce the risk of COVID-19 Negative pregnancy test for β-hCG on the day of screening and the day of vaccination Clinical trial participants should refrain from donating blood or plasma from the first vaccination until 3 months after the last vaccination. Participants should not enter any other trial while in this study Expressing a person's readiness to remain among the people monitored in the study for the entire study period until the research process is completed within 14 months Use one of a safe method of contraception in men and women up to 3 months after the last dose of the vaccine