Any acute or chronic symptomatic disease requiring ongoing medical or surgical care at the screening day Healthcare workers Breastfeeding History of receiving any vaccine (whether investigational or non-investigational) within 30 days prior to the screening day History of receiving other investigational drugs within 60 days prior to the screening day History of receiving blood or any blood product or immunoglobulin within three months prior to the screening day History of Immunodeficiency disorders (suspected or definite) History of long-term use of immunosuppressive drugs (more than 14 consecutive days) within four months prior to the screening day History of long-term use (more than 14 consecutive days) of systemic corticosteroids (equivalent to 10 mg or more daily prednisolone) or high-dose inhaled steroids (more than 800 µg/day of beclomethasone dipropionate or equivalent) within four months prior to the screening day (excluding topical steroids) History of allergic diseases such as angioedema or anaphylaxis History of any known allergy to drugs or vaccines including aluminum phosphate and albumin History of known allergy to eggs History of autoimmune diseases Chemotherapy or radiotherapy in the last 5 years History of cancer in the last 5 years History of serious psychiatric illnesses History of blood disorders (dyscrasia, coagulation disorders, platelet deficiency or disorder, deficiency of blood factors) History of chronic obstructive pulmonary disease such as asthma diagnosed by a specialist History of ischemic heart disease currently treated by a cardiologist or receiving any cardiac interventions History of hypertension currently treated by a physician History of diabetes currently treated by a physician Congenital anomalies, growth retardation, genetic defects or severe malnutrition Individual or family history of chronic neurological diseases (including seizures and epilepsy) History of thyroid disease or Thyroidectomy Any history of substance or alcohol abuse in the past 2 years Abnormal hematological or biochemical test results at the time of screening History of confirmed COVID-19 Acute febrile illness at the time of vaccination History of allergy to acetaminophen History of acute or chronic hepatitis B and C History of pulmonary or extrapulmonary tuberculosis or receiving antituberculotic treatment Receiving tuberculosis prophylaxis History of faint in any encounter with needles or phlebectomy Splenectomy for any reason or history of abnormal spleen function Any close contact with a confirmed COVID-19 case up to two weeks before receiving the first vaccine dose Previous history of diseases such as SARS and MERS Not fit to participate in the trial (the decision is at the discretion of the chief investigator) People who are currently serving their obligatory military service in the Armed Forces

Any acute or chronic symptomatic disease requiring ongoing medical or surgical care at the screening day Healthcare workers Breastfeeding History of receiving any vaccine (whether investigational or non-investigational) within 30 days prior to the screening day History of receiving other investigational drugs within 60 days prior to the screening day History of receiving blood or any blood product or immunoglobulin within three months prior to the screening day History of Immunodeficiency disorders (suspected or definite) History of long-term use of immunosuppressive drugs (more than 14 consecutive days) within four months prior to the screening day History of long-term use (more than 14 consecutive days) of systemic corticosteroids (equivalent to 10 mg or more daily prednisolone) or high-dose inhaled steroids (more than 800 µg/day of beclomethasone dipropionate or equivalent) within four months prior to the screening day (excluding topical steroids) History of allergic diseases such as angioedema or anaphylaxis History of any known allergy to drugs or vaccines including aluminum phosphate and albumin History of known allergy to eggs History of autoimmune diseases Chemotherapy or radiotherapy in the last 5 years History of cancer in the last 5 years History of serious psychiatric illnesses History of blood disorders (dyscrasia, coagulation disorders, platelet deficiency or disorder, deficiency of blood factors) History of chronic obstructive pulmonary disease such as asthma diagnosed by a specialist History of ischemic heart disease currently treated by a cardiologist or receiving any cardiac interventions History of hypertension currently treated by a physician History of diabetes currently treated by a physician Congenital anomalies, growth retardation, genetic defects or severe malnutrition Individual or family history of chronic neurological diseases (including seizures and epilepsy) History of thyroid disease or Thyroidectomy Any history of substance or alcohol abuse in the past 2 years Abnormal hematological or biochemical test results at the time of screening History of confirmed COVID-19 Acute febrile illness at the time of vaccination History of allergy to acetaminophen History of acute or chronic hepatitis B and C History of pulmonary or extrapulmonary tuberculosis or receiving antituberculotic treatment Receiving tuberculosis prophylaxis History of faint in any encounter with needles or phlebectomy Splenectomy for any reason or history of abnormal spleen function Any close contact with a confirmed COVID-19 case up to two weeks before receiving the first vaccine dose Previous history of diseases such as SARS and MERS Not fit to participate in the trial (the decision is at the discretion of the chief investigator) People who are currently serving their obligatory military service in the Armed Forces

History (at the time of referral) of any acute or chronic symptomatic disease requiring ongoing internal care or surgery Belonging to medical staff or health care workers Breastfeeding History of receiving any vaccine (whether investigational or non-investigational) within 30 days prior to screening History of receiving other investigational drugs during the last 60 days (before the start of the present clinical trial) History of receiving blood or any blood product or immunoglobulin within three months before screening History of Immunodeficiency disorders (suspected and definite) History of long-term use of immunosuppressive drugs (more than 14 consecutive days) within four months prior to screening History of long-term use (more than 14 consecutive days) of systemic corticosteroids (equivalent to 10 mg or more daily prednisolone) or (high-dose inhaled steroids (more than 800 µg/day of beclomethasone dipropionate or equivalent) within four months prior to screening (excluding topical steroids) History of allergic diseases such as angioedema or anaphylaxis History of any known allergy to the drug or vaccine carriers (whether alum or albumin) History of known allergy to eggs History of autoimmune diseases Chemotherapy or radiotherapy in the last 5 years History of cancer in the last 5 years History of serious psychiatric illnesses History of blood disorders (dyscrasia, coagulation disorders, platelet deficiency or disorder, deficiency of blood factors) History of chronic obstructive pulmonary disease such as asthma, ischemic heart disease definitively diagnosed by a specialist History of ischemic heart disease treated by a physician or history of cardiac interventions by a physician History of hypertension treated by a physician History of diabetes treated by a physician History of congenital anomalies, growth retardation, genetic defects or severe malnutrition Individual and family history of chronic neurological diseases (including seizures and epilepsy) History of thyroid disease or Thyroidectomy Any history of substance or alcohol abuse in the past 2 years Any defect in the results of hematology or biochemical tests performed at the time of screening History of confirmed COVID-19 Acute febrile illness at the time of vaccination History of allergy to acetaminophen History of acute or chronic hepatitis B and C History of pulmonary or extrapulmonary tuberculosis or receiving antituberculous agents Taking prophylactic antitubercular drugs History of syncope during injection or blood drawing Splenectomy for any reason or history of abnormal spleen function Any close contact with a person with confirmed COVID-19 for a maximum of two weeks before the day of receiving the first vaccine dose Previous history of diseases such as SARS and MERS Ineligibility to participate in a clinical trial for any reason at the discretion of the researchers Employment as military service in the subdivisions of the Armed Forces

History (at the time of referral) of any acute or chronic symptomatic disease requiring ongoing internal care or surgery Belonging to medical staff or health care workers Breastfeeding History of receiving any vaccine (whether investigational or non-investigational) within 30 days prior to screening History of receiving other investigational drugs during the last 60 days (before the start of the present clinical trial) History of receiving blood or any blood product or immunoglobulin within three months before screening History of Immunodeficiency disorders (suspected and definite) History of long-term use of immunosuppressive drugs (more than 14 consecutive days) within four months prior to screening History of long-term use (more than 14 consecutive days) of systemic corticosteroids (equivalent to 10 mg or more daily prednisolone) or (high-dose inhaled steroids (more than 800 µg/day of beclomethasone dipropionate or equivalent) within four months prior to screening (excluding topical steroids) History of allergic diseases such as angioedema or anaphylaxis History of any known allergy to the drug or vaccine carriers (whether alum or albumin) History of known allergy to eggs History of autoimmune diseases Chemotherapy or radiotherapy in the last 5 years History of cancer in the last 5 years History of serious psychiatric illnesses History of blood disorders (dyscrasia, coagulation disorders, platelet deficiency or disorder, deficiency of blood factors) History of chronic obstructive pulmonary disease such as asthma, ischemic heart disease definitively diagnosed by a specialist History of ischemic heart disease treated by a physician or history of cardiac interventions by a physician History of hypertension treated by a physician History of diabetes treated by a physician History of congenital anomalies, growth retardation, genetic defects or severe malnutrition Individual and family history of chronic neurological diseases (including seizures and epilepsy) History of thyroid disease or Thyroidectomy Any history of substance or alcohol abuse in the past 2 years Any defect in the results of hematology or biochemical tests performed at the time of screening History of confirmed COVID-19 Acute febrile illness at the time of vaccination History of allergy to acetaminophen History of acute or chronic hepatitis B and C History of pulmonary or extrapulmonary tuberculosis or receiving antituberculous agents Taking prophylactic antitubercular drugs History of syncope during injection or blood drawing Splenectomy for any reason or history of abnormal spleen function Any close contact with a person with confirmed COVID-19 for a maximum of two weeks before the day of receiving the first vaccine dose Previous history of diseases such as SARS and MERS Ineligibility to participate in a clinical trial for any reason at the discretion of the researchers Employment as military service in the subdivisions of the Armed Forces

Current acute or chronic symptomatic illness that requires ongoing medical or surgical care high-risk occupations regarding risk of COVID-19, including medical staff, occupations with close contact with many client Serving in compulsory military service (soldiers) in the subdivisions of the Armed Forces Breastfeeding History of receiving any research vaccine during the 30 days prior to the day of screening History of transfusion of any blood product or immunoglobulin within the 3 months before the screening day History of long-term use of immunosuppressive drugs or systemic corticosteroids in the last 4 months leading up to screening day History of allergic diseases such as angioedema or anaphylactic reactions History of any allergy to drugs or vaccines History of cancer or chemotherapy in the last 5 years History of serious psychiatric illnesses History of blood disorders (Blood Dyscrasias, coagulation, platelet deficiency or disorder, etc) Having chronic obstructive pulmonary disease such as asthma and COPD, ischemic cardiovascular disease diagnosed and treated by a specialist. high blood pressure that is being treated by a doctor. diabetes that is being treated by a doctor. History of chronic neurological diseases (including seizures and epilepsy) Any history of drug abuse (addiction) or alcohol consumption during the last 2 years Any grade 1 toxicity in the hematology or biochemistry test results performed at the time of screening History of confirmed COVID-19 Acute or chronic hepatitis B and C Receiving prophylactic drug against tuberculosis History of syncope with injection or blood observation having a splenectomy for any reason Any close contact with a definitively infected person with COVID-19 for a maximum of two weeks before the day of receiving the first dose

Current acute or chronic symptomatic illness that requires ongoing medical or surgical care high-risk occupations regarding risk of COVID-19, including medical staff, occupations with close contact with many client Serving in compulsory military service (soldiers) in the subdivisions of the Armed Forces Breastfeeding History of receiving any research vaccine during the 30 days prior to the day of screening History of transfusion of any blood product or immunoglobulin within the 3 months before the screening day History of long-term use of immunosuppressive drugs or systemic corticosteroids in the last 4 months leading up to screening day History of allergic diseases such as angioedema or anaphylactic reactions History of any allergy to drugs or vaccines History of cancer or chemotherapy in the last 5 years History of serious psychiatric illnesses History of blood disorders (Blood Dyscrasias, coagulation, platelet deficiency or disorder, etc) Having chronic obstructive pulmonary disease such as asthma and COPD, ischemic cardiovascular disease diagnosed and treated by a specialist. high blood pressure that is being treated by a doctor. diabetes that is being treated by a doctor. History of chronic neurological diseases (including seizures and epilepsy) Any history of drug abuse (addiction) or alcohol consumption during the last 2 years Any grade 1 toxicity in the hematology or biochemistry test results performed at the time of screening History of confirmed COVID-19 Acute or chronic hepatitis B and C Receiving prophylactic drug against tuberculosis History of syncope with injection or blood observation having a splenectomy for any reason Any close contact with a definitively infected person with COVID-19 for a maximum of two weeks before the day of receiving the first dose