Acute respiratory distress Syndrome of moderate to severe type (PaO2/ FiO2 <200mmHg) Age range between 18 to 65 years Men and Women No participation in another clinical trial during this study Patients who have given themselves and their families a full explanation of the study process and have obtained informed written consent Chest X-ray showed bilateral infiltration with pulmonary edema Definitive infection with COVID-19 confirmed by PCR

Acute respiratory distress Syndrome of moderate to severe type (PaO2/ FiO2 <200mmHg) Age range between 18 to 65 years Men and Women No participation in another clinical trial during this study Patients who have given themselves and their families a full explanation of the study process and have obtained informed written consent Chest X-ray showed bilateral infiltration with pulmonary edema Definitive infection with COVID-19 confirmed by PCR