All COVID-19 patients whose disease has been confirmed by the PCR test for SARS-Cov-2. Having one of the criteria for severe COVID-19 disease includes tachypnea (respiration rate> 30 per minute), hypoxemia (O2 ≤ saturation, arterial oxygen partial pressure ratio <300), pulmonary infiltration (> 50% of lung area during 24 48 h), LDH> 245 U / l, Progressive lymphopenia. Hospitalized in the intensive care unit. Signing the written consent of the study participant.

All COVID-19 patients whose disease has been confirmed by the PCR test for SARS-Cov-2. Having one of the criteria for severe COVID-19 disease includes tachypnea (respiration rate> 30 per minute), hypoxemia (O2 ≤ saturation, arterial oxygen partial pressure ratio <300), pulmonary infiltration (> 50% of lung area during 24 48 h), LDH> 245 U / l, Progressive lymphopenia. Hospitalized in the intensive care unit. Signing the written consent of the study participant.