Having Iranian citizenship; Diploma or higher degree; Adults aged 18 - 55 years; Body mass index 17 to 35 kg/m2; Having good health based on clinical and laboratory criteria; Having sublingual temperature less than or equal to 37.2 ° C in the morning based on mercury thermometer; Negative IgG and IgM antibody titers for COVID-19 S antigen; Negative RT-PCR test for COVID-19; Negative IgG ELISA for HIV; Having heart rate between 60 and 100; Signed the informed consent form; The participant agrees to reduce the risk of developing of COVID-19; For females of childbearing age 18 to 49 years: not being pregnant based on the first day of the last menstrual period; For females of childbearing age 18 to 49 years: negative pregnancy test based on bHCG on the day of screening and the day of vaccination; For females of childbearing age 18 to 49 years: use at least one effective method of contraception (condoms, oral contraceptive pills, intrauterine device, Norplant capsule) and willing to continue using it up to three month after last vaccine dose; Unwillingness to have children and use effective methods of contraception up to three months after completion of vaccination (all participants). Confirmation by a psychiatrist that the participant's mental health and capacity allows him/her to make a decision regarding his/her participation in the trial.

Having Iranian citizenship; Diploma or higher degree; Adults aged 18 - 55 years; Body mass index 17 to 35 kg/m2; Having good health based on clinical and laboratory criteria; Having sublingual temperature less than or equal to 37.2 ° C in the morning based on mercury thermometer; Negative IgG and IgM antibody titers for COVID-19 S antigen; Negative RT-PCR test for COVID-19; Negative IgG ELISA for HIV; Having heart rate between 60 and 100; Signed the informed consent form; The participant agrees to reduce the risk of developing of COVID-19; For females of childbearing age 18 to 49 years: not being pregnant based on the first day of the last menstrual period; For females of childbearing age 18 to 49 years: negative pregnancy test based on bHCG on the day of screening and the day of vaccination; For females of childbearing age 18 to 49 years: use at least one effective method of contraception (condoms, oral contraceptive pills, intrauterine device, Norplant capsule) and willing to continue using it up to three month after last vaccine dose; Unwillingness to have children and use effective methods of contraception up to three months after completion of vaccination (all participants). Confirmation by a psychiatrist that the participant's mental health and capacity allows him/her to make a decision regarding his/her participation in the trial.