Any ongoing, symptomatic acute or chronic illness requiring medical or surgical care on the day of vaccination; Working in an occupation with a high risk of exposure to COVID-19 including medical staff, occupations with close contact with the client; Breastfeeding; Receipt any vaccine during the 30 days before the screening day; Received blood and/or any blood products and/or immunoglobulins within three months preceding the screening day; Any confirmed or suspected immunodeficient state; History of long-term use of immunosuppressive medication (defined as more than 14 continuous days) in the last 4 months leading up to screening day; Long-term use (defined as more than 14 continuous days) of systemic corticosteroids (equivalent to 10 mg or more daily prednisolone) within the past 4 months, except topical steroids; History of allergic diseases such as angioedema or anaphylactic reactions; History of any allergy to the drug or vaccine (defined as any clinical signs or symptom of itching at the injection site, urticaria in the body after injection, excessive redness at the injection site); History of autoimmune diseases (other than controlled autoimmune thyroid disease, stable celiac disease, mild psoriasis, vitiligo that does not require corticosteroid or immunosuppressive therapy); History of chemotherapy in the last 5 years; History of cancer in the last 5 years; History of serious psychiatric illnesses; History of blood disorders (dyscrasia, coagulopathy, platelet deficiency or disorder, deficiency of blood factors); Suffering from chronic obstructive pulmonary disease such as asthma and COPD that diagnosed by a specialist and is/was under medication; Suffering from ischemic heart disease that is/was under medication by a specialist , history of cardiac interventions; Suffering from hypertension that is/was under medication by a specialist ; Suffering from diabetes that is/was under medication by a specialist ; History of chronic neurological diseases (including seizures and epilepsy); Any history of substance or alcohol abuse within the last 2 years; Any abnormality in the hematology or biochemical laboratory tests based on FDA toxicity score (grade >1) on the screening day; History of confirmed COVID-19; Acute febrile illness at the time of vaccination; History of acetaminophen allergy; Acute or chronic hepatitis B and C; Receiving prophylactic drug against tuberculosis; History of syncope with blood transfusion or blood observation; Splenectomy for any reason; Any close contact with a confirmed COVID-19 case within two weeks before the first dose of vaccine; History of SARS or MERS; Participate in any clinical trials (research) study other than this study.

Any ongoing, symptomatic acute or chronic illness requiring medical or surgical care on the day of vaccination; Working in an occupation with a high risk of exposure to COVID-19 including medical staff, occupations with close contact with the client; Breastfeeding; Receipt any vaccine during the 30 days before the screening day; Received blood and/or any blood products and/or immunoglobulins within three months preceding the screening day; Any confirmed or suspected immunodeficient state; History of long-term use of immunosuppressive medication (defined as more than 14 continuous days) in the last 4 months leading up to screening day; Long-term use (defined as more than 14 continuous days) of systemic corticosteroids (equivalent to 10 mg or more daily prednisolone) within the past 4 months, except topical steroids; History of allergic diseases such as angioedema or anaphylactic reactions; History of any allergy to the drug or vaccine (defined as any clinical signs or symptom of itching at the injection site, urticaria in the body after injection, excessive redness at the injection site); History of autoimmune diseases (other than controlled autoimmune thyroid disease, stable celiac disease, mild psoriasis, vitiligo that does not require corticosteroid or immunosuppressive therapy); History of chemotherapy in the last 5 years; History of cancer in the last 5 years; History of serious psychiatric illnesses; History of blood disorders (dyscrasia, coagulopathy, platelet deficiency or disorder, deficiency of blood factors); Suffering from chronic obstructive pulmonary disease such as asthma and COPD that diagnosed by a specialist and is/was under medication; Suffering from ischemic heart disease that is/was under medication by a specialist , history of cardiac interventions; Suffering from hypertension that is/was under medication by a specialist ; Suffering from diabetes that is/was under medication by a specialist ; History of chronic neurological diseases (including seizures and epilepsy); Any history of substance or alcohol abuse within the last 2 years; Any abnormality in the hematology or biochemical laboratory tests based on FDA toxicity score (grade >1) on the screening day; History of confirmed COVID-19; Acute febrile illness at the time of vaccination; History of acetaminophen allergy; Acute or chronic hepatitis B and C; Receiving prophylactic drug against tuberculosis; History of syncope with blood transfusion or blood observation; Splenectomy for any reason; Any close contact with a confirmed COVID-19 case within two weeks before the first dose of vaccine; History of SARS or MERS; Participate in any clinical trials (research) study other than this study.