Age ≥18 years at time of signing Informed Consent Form Laboratory (RT-PCR) confirmed infection with COVID-19 Lung involvement confirmed with chest imaging Hospitalized with a SaO2/SPO2≤94% on room air or PaO2/FiO2 ratio <300mgHg ≤12 days since illness onset Willingness of study participant to accept randomization to any assigned treatment arm Must agree not to enroll in another study of an investigational agent prior to completion of Day 28 of study

Age ≥18 years at time of signing Informed Consent Form Laboratory (RT-PCR) confirmed infection with COVID-19 Lung involvement confirmed with chest imaging Hospitalized with a SaO2/SPO2≤94% on room air or PaO2/FiO2 ratio <300mgHg ≤12 days since illness onset Willingness of study participant to accept randomization to any assigned treatment arm Must agree not to enroll in another study of an investigational agent prior to completion of Day 28 of study