age< 18 years old No compliance for drug consumption Very old age patients and the patients with mental disturbance which can not cooperate. the patients who use other chemical and/or traditional drugs the patients with underlying diseases such as Hypertention the patients who use antiseptic oral solutions the patients who use antiviral drugs

age< 18 years old No compliance for drug consumption Very old age patients and the patients with mental disturbance which can not cooperate. the patients who use other chemical and/or traditional drugs the patients with underlying diseases such as Hypertention the patients who use antiseptic oral solutions the patients who use antiviral drugs