18-75 year old men and 50-75 year old women admitted in hospital Spo2 less than 85% in admission Clinical symptoms and signs compatible with COVID19 infection and positive PCR test or lung HRCT abnormalities compatible with COVID19 pneumonia No need to intubation in first 24 hour of admission No multiorgan failure at presentation No shock state at presentation Obtained informed consent

18-75 year old men and 50-75 year old women admitted in hospital Spo2 less than 85% in admission Clinical symptoms and signs compatible with COVID19 infection and positive PCR test or lung HRCT abnormalities compatible with COVID19 pneumonia No need to intubation in first 24 hour of admission No multiorgan failure at presentation No shock state at presentation Obtained informed consent