Known hypersensitivity to indomethacin or any components of NSAIDs History of asthma, urticarial, or other allergic type reaction after taking aspirin or NSAIDs GFR less than 60ml/minute/1.7m2 Patients with active gastrointestinal bleeding The need for intubation in the first 24 hours of hospitalization Patients with multi organ failure Patients with shock state at admission Pregnant woman Lactating woman Patients with active peptic ulcer Consumption of NSAID on admission

Known hypersensitivity to indomethacin or any components of NSAIDs History of asthma, urticarial, or other allergic type reaction after taking aspirin or NSAIDs GFR less than 60ml/minute/1.7m2 Patients with active gastrointestinal bleeding The need for intubation in the first 24 hours of hospitalization Patients with multi organ failure Patients with shock state at admission Pregnant woman Lactating woman Patients with active peptic ulcer Consumption of NSAID on admission