Patients in acute phase Laboratory confirmation of SARS-COV-2 infection Pneumonia confirmed by chest x-ray or tomography Respiratory rate> 30 times / minute Oxygen Saturation less than 93% Arterial oxygen partial pressure (Pao2) /oxygen inhalation(Fio2) less than 300 mmHg No history of tumor or malignant disease

Patients in acute phase Laboratory confirmation of SARS-COV-2 infection Pneumonia confirmed by chest x-ray or tomography Respiratory rate> 30 times / minute Oxygen Saturation less than 93% Arterial oxygen partial pressure (Pao2) /oxygen inhalation(Fio2) less than 300 mmHg No history of tumor or malignant disease