Older than 18 years old admission with moderate to severe COVID-19 based on WHO definition Illness of any duration, and at least one of the following: Radiographic infiltrates by imaging (chest x-ray, CT scan, etc.), or Clinical assessment AND respiratory rate > 30 breaths/min; or severe respiratory distress; or SpO2 < 90% on room air. Willing and be able to provide written informed consent prior to performing study procedures

Older than 18 years old admission with moderate to severe COVID-19 based on WHO definition Illness of any duration, and at least one of the following: Radiographic infiltrates by imaging (chest x-ray, CT scan, etc.), or Clinical assessment AND respiratory rate > 30 breaths/min; or severe respiratory distress; or SpO2 < 90% on room air. Willing and be able to provide written informed consent prior to performing study procedures

Older than 18 years old admission with moderate to severe COVID-19 based on WHO definition Illness of any duration, and at least one of the following: Radiographic infiltrates by imaging (chest x-ray, CT scan, etc.), or Clinical assessment AND SpO2 ≤ 94% on room air, Willing and be able to provide written informed consent prior to performing study procedures

Older than 18 years old admission with moderate to severe COVID-19 based on WHO definition Illness of any duration, and at least one of the following: Radiographic infiltrates by imaging (chest x-ray, CT scan, etc.), or Clinical assessment AND SpO2 ≤ 94% on room air, Willing and be able to provide written informed consent prior to performing study procedures