use of protease inhibitors like kaletra history of allergy to colchicine pregnancy and lactation hepatic failure (child pugh C), kidney failure (GFR<30 ml/min), or heart failure with EF<40% concomitant use of CYP3A4 or pgp potent inhibitors or inducers concomitant use of statins except rosuvastatin active GI disturbances like active peptic ulcers transmission of patients to ICU ward or his/her intubation patients on colchicine for behcet disease or Mediterranean fever or gout patients with history of neuromuscular disease or chronic diarrhea or malabsorption

use of protease inhibitors like kaletra history of allergy to colchicine pregnancy and lactation hepatic failure (child pugh C), kidney failure (GFR<30 ml/min), or heart failure with EF<40% concomitant use of CYP3A4 or pgp potent inhibitors or inducers concomitant use of statins except rosuvastatin active GI disturbances like active peptic ulcers transmission of patients to ICU ward or his/her intubation patients on colchicine for behcet disease or Mediterranean fever or gout patients with history of neuromuscular disease or chronic diarrhea or malabsorption