• Women who are pregnant, breastfeeding or actively trying to achieve a pregnancy • Current hospital inpatient with COVID-19 related disease • Allergy to ivermectin, doxycycline or famotidine • Known bleeding disorder • Known severe liver disease • Diagnosis of Myasthenia Gravis/SLE • Consumption of grapefruit juice • Ever travelled to countries that are endemic for Loa loa (West and Central Africa – Angola, Cameroon, Central African Republic, Democratic Republic of Congo, Ethiopia, Guinea, Gabon, Republic of Congo, Nigeria and Sudan) • Currently on the following medications: o Cardiac - quinidine, amiodarone, diltiazem, verapamil, warfarin o Anti-infective – clarithromycin, erythromycin, itraconazole, ketoconazole, o Anti-viral – indinavir, ritonavir, cobicistat o Disease modifying – cyclosporine, tacrolimus, sirolimus, methotrexate o Other – retinoids, lithium, spironlactone Neither minority groups nor NESB/LOTE persons will be excluded provided they possess the capacity (ie ability to understand, retain, comprehend and dutifully consider a response) to consent.

• Women who are pregnant, breastfeeding or actively trying to achieve a pregnancy • Current hospital inpatient with COVID-19 related disease • Allergy to ivermectin, doxycycline or famotidine • Known bleeding disorder • Known severe liver disease • Diagnosis of Myasthenia Gravis/SLE • Consumption of grapefruit juice • Ever travelled to countries that are endemic for Loa loa (West and Central Africa – Angola, Cameroon, Central African Republic, Democratic Republic of Congo, Ethiopia, Guinea, Gabon, Republic of Congo, Nigeria and Sudan) • Currently on the following medications: o Cardiac - quinidine, amiodarone, diltiazem, verapamil, warfarin o Anti-infective – clarithromycin, erythromycin, itraconazole, ketoconazole, o Anti-viral – indinavir, ritonavir, cobicistat o Disease modifying – cyclosporine, tacrolimus, sirolimus, methotrexate o Other – retinoids, lithium, spironlactone Neither minority groups nor NESB/LOTE persons will be excluded provided they possess the capacity (ie ability to understand, retain, comprehend and dutifully consider a response) to consent.