1. Patients with unstable disease activity and past history of flare following vaccinations. <br/ > 2. Patients with non-repopulated peripheral B cell, if they have taken B cell depletion therapy 3. Patients with past history of Covid infection 4. Patients with history of allergic reaction to vaccine or its components <br/ > 5. Patients who received any live vaccine within 2 months prior the study. 6. Patients with history of arterial/ venous thrombosis, demyelinating syndromes or diagnosed case of vasculitis

1. Patients with unstable disease activity and past history of flare following vaccinations. <br/ > 2. Patients with non-repopulated peripheral B cell, if they have taken B cell depletion therapy 3. Patients with past history of Covid infection 4. Patients with history of allergic reaction to vaccine or its components <br/ > 5. Patients who received any live vaccine within 2 months prior the study. 6. Patients with history of arterial/ venous thrombosis, demyelinating syndromes or diagnosed case of vasculitis