1. Age: â?¥18 â?? â?¤65 years old, male and female patients hospitalized for Covid 19 infection. <br/ > 2. Recently admitted in ICU (i.e. Enrollment/Randomization should occur within 48 hours of ICU admission). <br/ > 3. Radiologically confirmed pneumonia. <br/ > 4. Laboratory confirmed Covid19 infection. <br/ > 5. Severe COVID 19 pneumonia with ARDS defined as patients with clinical signs of pneumonia plus one of the following: <br/ > a. respiratory rate >30 breaths/min <br/ > b. severe respiratory distress or SpO2 <90% on room air. <br/ > 6. Patients on different modalities of oxygen therapy â?? High Flow Nasal Cannula Oxygen ( >0.4 FiO /30 L/min of oxygen flow) or non-invasive ventilation. <br/ > 7. Presence of raised inflammatory markers in any one of the following: CRP (CRP > 75 mg/L) or Ferritin (â?¥ 5 times Upper Limit of Normal) or IL-6 ( >40 pg/ml) or D dimer ( >1.5 μgFEU/ml). <br/ > 8. Procalcitonin in normal range ( <0.3 μg/L). <br/ > 9. Women of childbearing potential or men capable of fathering children must agree to use adequate birth control measures (e.g., abstinence, oral contraceptives, intrauterine device, barrier method with spermicide, surgical sterilization) during the study and for 6 months after receiving the last administration of study drug. Women of childbearing potential must test negative for pregnancy at screening.

1. Age: â?¥18 â?? â?¤65 years old, male and female patients hospitalized for Covid 19 infection. <br/ > 2. Recently admitted in ICU (i.e. Enrollment/Randomization should occur within 48 hours of ICU admission). <br/ > 3. Radiologically confirmed pneumonia. <br/ > 4. Laboratory confirmed Covid19 infection. <br/ > 5. Severe COVID 19 pneumonia with ARDS defined as patients with clinical signs of pneumonia plus one of the following: <br/ > a. respiratory rate >30 breaths/min <br/ > b. severe respiratory distress or SpO2 <90% on room air. <br/ > 6. Patients on different modalities of oxygen therapy â?? High Flow Nasal Cannula Oxygen ( >0.4 FiO /30 L/min of oxygen flow) or non-invasive ventilation. <br/ > 7. Presence of raised inflammatory markers in any one of the following: CRP (CRP > 75 mg/L) or Ferritin (â?¥ 5 times Upper Limit of Normal) or IL-6 ( >40 pg/ml) or D dimer ( >1.5 μgFEU/ml). <br/ > 8. Procalcitonin in normal range ( <0.3 μg/L). <br/ > 9. Women of childbearing potential or men capable of fathering children must agree to use adequate birth control measures (e.g., abstinence, oral contraceptives, intrauterine device, barrier method with spermicide, surgical sterilization) during the study and for 6 months after receiving the last administration of study drug. Women of childbearing potential must test negative for pregnancy at screening.