1. Patients with active / latent tuberculosis <br/ > 2. Patients with pre - existing AKI, EGFR < 15ml/min <br/ > 3. Patients with deranged liver function test <br/ > 4. Patients with history of chronic dialysis and renal transplant <br/ > 5. Patients with history of thrombophlebitis and acute / chronic autoimmune disorder <br/ > 6. Patients with serology positive <br/ > 7. Patients on immunosuppressive drugs <br/ > 8. Pregnant and lactation

1. Patients with active / latent tuberculosis <br/ > 2. Patients with pre - existing AKI, EGFR < 15ml/min <br/ > 3. Patients with deranged liver function test <br/ > 4. Patients with history of chronic dialysis and renal transplant <br/ > 5. Patients with history of thrombophlebitis and acute / chronic autoimmune disorder <br/ > 6. Patients with serology positive <br/ > 7. Patients on immunosuppressive drugs <br/ > 8. Pregnant and lactation