1. known allergy or hypersensitivity to ifnß-1a or ifnß-1b 2. presence of severe concomitant illnesses/medical conditions that in the physician opinion do not allow participation to the study 3. pregnant or lactating females 4. history of major depression disorder or suicidal attempt or suicidal ideation 5. spontaneous blood alanine aminotransferase/aspartate aminotransferase (alt/ast) levels \> 5 times the upper limit of normal 6. clinical status defined as 1, 2, or 6 on the 7-point ordinal scale

1. known allergy or hypersensitivity to ifnß-1a or ifnß-1b 2. presence of severe concomitant illnesses/medical conditions that in the physician opinion do not allow participation to the study 3. pregnant or lactating females 4. history of major depression disorder or suicidal attempt or suicidal ideation 5. spontaneous blood alanine aminotransferase/aspartate aminotransferase (alt/ast) levels \> 5 times the upper limit of normal 6. clinical status defined as 1, 2, or 6 on the 7-point ordinal scale

known allergy or hypersensitivity to ifnß-1a or ifnß-1b presence of severe concomitant illnesses/medical conditions that in the physician opinion do not allow participation to the study pregnant or lactating females history of major depression disorder or suicidal attempt or suicidal ideation spontaneous blood alanine aminotransferase/aspartate aminotransferase (alt/ast) levels > 5 times the upper limit of normal clinical status defined as 1, 2, or 6 on the 7-point ordinal scale

known allergy or hypersensitivity to ifnß-1a or ifnß-1b presence of severe concomitant illnesses/medical conditions that in the physician opinion do not allow participation to the study pregnant or lactating females history of major depression disorder or suicidal attempt or suicidal ideation spontaneous blood alanine aminotransferase/aspartate aminotransferase (alt/ast) levels > 5 times the upper limit of normal clinical status defined as 1, 2, or 6 on the 7-point ordinal scale

1. known allergy or hypersensitivity to ifnß-1a or ifnß-1b 2. presence of severe concomitant illnesses/medical conditions that in the physician opinion do not allow participation to the study 3. pregnant or lactating females 4. history of major depression disorder or suicidal attempt or suicidal ideation 5. spontaneous blood alanine aminotransferase/aspartate aminotransferase (alt/ast) levels > 5 times the upper limit of normal 6. clinical status defined as 1, 2, or 6 on the 7-point ordinal scale

1. known allergy or hypersensitivity to ifnß-1a or ifnß-1b 2. presence of severe concomitant illnesses/medical conditions that in the physician opinion do not allow participation to the study 3. pregnant or lactating females 4. history of major depression disorder or suicidal attempt or suicidal ideation 5. spontaneous blood alanine aminotransferase/aspartate aminotransferase (alt/ast) levels > 5 times the upper limit of normal 6. clinical status defined as 1, 2, or 6 on the 7-point ordinal scale