1. Definite indication for colchicine, such as gout or pericarditis <br/ > 2. Contraindication to colchicine, including: <br/ > a. Hypersensitivity. <br/ > b. Pregnant, breastfeeding or of childbearing age and not using an acceptable method of <br/ > contraception. <br/ > c. Currently taking or might need during the trial, a concomitant treatment which is contraindicated with colchicine: cyclosporin, strong CYP3A4 inhibitors, phenylbutazone, immunosuppressants and anti-neoplastic agents. <br/ > 3. Current/history of inflammatory bowel disease, chronic diarrhea, blood dyscrasias or <br/ > eGFR <15mL/min/1.73m2. <br/ > 4. Current surgical or medical condition that might significantly alter the absorption, distribution, metabolism, or excretion of trial drugs such as prior major gastrointestinal tract surgery (e.g. gastrectomy, lap band, or bowel resection). <br/ > 5. History of alcohol or drug dependence within 12 months. <br/ > 6. Significant cognitive impairment precluding consent

1. Definite indication for colchicine, such as gout or pericarditis <br/ > 2. Contraindication to colchicine, including: <br/ > a. Hypersensitivity. <br/ > b. Pregnant, breastfeeding or of childbearing age and not using an acceptable method of <br/ > contraception. <br/ > c. Currently taking or might need during the trial, a concomitant treatment which is contraindicated with colchicine: cyclosporin, strong CYP3A4 inhibitors, phenylbutazone, immunosuppressants and anti-neoplastic agents. <br/ > 3. Current/history of inflammatory bowel disease, chronic diarrhea, blood dyscrasias or <br/ > eGFR <15mL/min/1.73m2. <br/ > 4. Current surgical or medical condition that might significantly alter the absorption, distribution, metabolism, or excretion of trial drugs such as prior major gastrointestinal tract surgery (e.g. gastrectomy, lap band, or bowel resection). <br/ > 5. History of alcohol or drug dependence within 12 months. <br/ > 6. Significant cognitive impairment precluding consent