To be eligible to participate in this study, an individual must meet all of the following criteria 1.Willingness to provide a signed and dated informed consent form. 2.Stated willingness to comply with all study procedures and availability for the duration of the study. 3.Be a Thai male or female 18 years of age or older. 4.For females- Be of non-childbearing potential or willing to use appropriate contraceptive measures for 30 days prior to vaccination through two months after completion of the vaccine series. Non-childbearing potential means being surgically sterilized or at least one year post-menopausal. Appropriate measures to prevent pregnancy include abstinence or adequate contraceptive precautions (i.e. intrauterine or implantable contraceptive device, oral contraceptives-diaphragm or condom in combination with contraceptive jelly, cream or foam). 5.For healthy participants with pre-existing medical conditions-Be in stable condition that has not worsened over the three months before enrollment to require hospitalization or significant changes in therapy.

To be eligible to participate in this study, an individual must meet all of the following criteria 1.Willingness to provide a signed and dated informed consent form. 2.Stated willingness to comply with all study procedures and availability for the duration of the study. 3.Be a Thai male or female 18 years of age or older. 4.For females- Be of non-childbearing potential or willing to use appropriate contraceptive measures for 30 days prior to vaccination through two months after completion of the vaccine series. Non-childbearing potential means being surgically sterilized or at least one year post-menopausal. Appropriate measures to prevent pregnancy include abstinence or adequate contraceptive precautions (i.e. intrauterine or implantable contraceptive device, oral contraceptives-diaphragm or condom in combination with contraceptive jelly, cream or foam). 5.For healthy participants with pre-existing medical conditions-Be in stable condition that has not worsened over the three months before enrollment to require hospitalization or significant changes in therapy.