* critical covid-19 illness (map \< 60 mm hg, on mechanical ventilator for ≥ 5 days) * on maintenance hemodialysis or peritoneal dialysis * child pugh c cirrhosis * hepatorenal syndrome * ascites and/or hepatic encephalopathy * history of end stage renal disease or ckd with egfr \< 15 ml/min/1.73m2 * women who are pregnant or breast feeding * receipt of other concomitant experimental therapies

* critical covid-19 illness (map \< 60 mm hg, on mechanical ventilator for ≥ 5 days) * on maintenance hemodialysis or peritoneal dialysis * child pugh c cirrhosis * hepatorenal syndrome * ascites and/or hepatic encephalopathy * history of end stage renal disease or ckd with egfr \< 15 ml/min/1.73m2 * women who are pregnant or breast feeding * receipt of other concomitant experimental therapies

- critical covid-19 illness (map < 60 mm hg, on mechanical ventilator for ≥ 5 days) - on maintenance hemodialysis or peritoneal dialysis - child pugh c cirrhosis - hepatorenal syndrome - ascites and/or hepatic encephalopathy - history of end stage renal disease or ckd with egfr < 15 ml/min/1.73m2 - women who are pregnant or breast feeding - receipt of other concomitant experimental therapies

- critical covid-19 illness (map < 60 mm hg, on mechanical ventilator for ≥ 5 days) - on maintenance hemodialysis or peritoneal dialysis - child pugh c cirrhosis - hepatorenal syndrome - ascites and/or hepatic encephalopathy - history of end stage renal disease or ckd with egfr < 15 ml/min/1.73m2 - women who are pregnant or breast feeding - receipt of other concomitant experimental therapies