patients• patients not willing to or unable to get vaccinated• patients with a duration of remission of = 5 years• patients unable to give consenthealthy subjects• subjects not willing to or unable to get vaccinated according to recommendations of the Robert-Koch-Institut• subjects with a malignant disease and a duration of remission of < 5 years• subjects unable to give consent

patients• patients not willing to or unable to get vaccinated• patients with a duration of remission of = 5 years• patients unable to give consenthealthy subjects• subjects not willing to or unable to get vaccinated according to recommendations of the Robert-Koch-Institut• subjects with a malignant disease and a duration of remission of < 5 years• subjects unable to give consent