1. Women who are in the menstrual period (day 1 to day 4 of menstrual cramps) or breastfeeding on the day of vaccination, or men whose partners plan to become pregnant within 12 months from the screening period to the full immunization period, or plan to donate sperm and eggs, 2. Those who have a history of new coronavirus vaccination, 3. People who have been diagnosed with new coronavirus pneumonia cases or suspected cases, have contact history with confirmed or suspected cases of new coronavirus within 1 month before signing the informed consent, or have travel experience in high-risk areas of the epidemic or overseas, or new coronavirus Infected persons or carriers: serum anti-SARS-CoV-2 IgG, IgM specific antibodies are positive, or throat swab specimens are positive for SARS-CoV-2 nucleic acid, 4. Those who test positive for hepatitis B surface antigen, hepatitis C virus antibody, Treponema pallidum specific antibody, and human immunodeficiency virus antibody, 5. A history of SARS, MERS and other human coronavirus infections or disease history, 6. Acute illness or acute onset of chronic disease occurred within 2 weeks before the first dose of vaccine, or fever (axillary body temperature =37.3?) or symptoms of upper respiratory tract infection within 7 days before the first dose of vaccine, 7. Past alcohol or history of serious adverse reactions to any vaccine or drugs (for example: allergies, urticaria, skin eczema, allergic purpura, dyspnea, angioedema, etc.), or history of allergy to acetaminophen, 8. Have received any vaccine within 1 month before the first dose of vaccine, 9. Those who cannot tolerate venipuncture, and those who have a history of fainting needles and bleeding, 10. Have hereditary bleeding tendency or coagulation dysfunction, or have a history of thrombosis or hemorrhagic disease, and the test results of coagulation function-related indicators are abnormal, 11. Has been diagnosed with congenital or acquired immunodeficiency (for example: HIV infection), 12. No spleen, functional no spleen, and surgical removal of other important organs for any reason, 13. Severe diseases that have abnormal clinical manifestations and need to be excluded, including but not limited to nervous system, cardiovascular system, blood and lymphatic system, immune system, kidney, liver, gastrointestinal tract, respiratory system, metabolism, bones and other system diseases And the history of malignant tumors, excluding the history of stable chronic diseases, such as diabetes, hypertension, etc., 14. Those who have undergone surgery within 3 months before signing the informed consent, or who plan to undergo surgery during the trial period or within 3 months after the end of the trial (including cosmetic surgery, dental surgery and oral surgery), 15. Those who donate blood or lose blood (>=450 mL) within 3 months before signing the informed consent, receive blood transfusion or use blood products, or plan to donate blood during the trial period, 16. Any research or unregistered products (drugs, vaccines, biological products or devices) have been used within 3 months before signing the informed consent, or planned to be used during the research period, 17. Receive immunosuppressive therapy within 6 months before signing the informed consent form, such as long-term application of systemic glucocorticoid therapy (for more than 2 consecutive weeks in 6 months, application of systemic glucocorticoid therapy, such as prednisone or

1. Women who are in the menstrual period (day 1 to day 4 of menstrual cramps) or breastfeeding on the day of vaccination, or men whose partners plan to become pregnant within 12 months from the screening period to the full immunization period, or plan to donate sperm and eggs, 2. Those who have a history of new coronavirus vaccination, 3. People who have been diagnosed with new coronavirus pneumonia cases or suspected cases, have contact history with confirmed or suspected cases of new coronavirus within 1 month before signing the informed consent, or have travel experience in high-risk areas of the epidemic or overseas, or new coronavirus Infected persons or carriers: serum anti-SARS-CoV-2 IgG, IgM specific antibodies are positive, or throat swab specimens are positive for SARS-CoV-2 nucleic acid, 4. Those who test positive for hepatitis B surface antigen, hepatitis C virus antibody, Treponema pallidum specific antibody, and human immunodeficiency virus antibody, 5. A history of SARS, MERS and other human coronavirus infections or disease history, 6. Acute illness or acute onset of chronic disease occurred within 2 weeks before the first dose of vaccine, or fever (axillary body temperature =37.3?) or symptoms of upper respiratory tract infection within 7 days before the first dose of vaccine, 7. Past alcohol or history of serious adverse reactions to any vaccine or drugs (for example: allergies, urticaria, skin eczema, allergic purpura, dyspnea, angioedema, etc.), or history of allergy to acetaminophen, 8. Have received any vaccine within 1 month before the first dose of vaccine, 9. Those who cannot tolerate venipuncture, and those who have a history of fainting needles and bleeding, 10. Have hereditary bleeding tendency or coagulation dysfunction, or have a history of thrombosis or hemorrhagic disease, and the test results of coagulation function-related indicators are abnormal, 11. Has been diagnosed with congenital or acquired immunodeficiency (for example: HIV infection), 12. No spleen, functional no spleen, and surgical removal of other important organs for any reason, 13. Severe diseases that have abnormal clinical manifestations and need to be excluded, including but not limited to nervous system, cardiovascular system, blood and lymphatic system, immune system, kidney, liver, gastrointestinal tract, respiratory system, metabolism, bones and other system diseases And the history of malignant tumors, excluding the history of stable chronic diseases, such as diabetes, hypertension, etc., 14. Those who have undergone surgery within 3 months before signing the informed consent, or who plan to undergo surgery during the trial period or within 3 months after the end of the trial (including cosmetic surgery, dental surgery and oral surgery), 15. Those who donate blood or lose blood (>=450 mL) within 3 months before signing the informed consent, receive blood transfusion or use blood products, or plan to donate blood during the trial period, 16. Any research or unregistered products (drugs, vaccines, biological products or devices) have been used within 3 months before signing the informed consent, or planned to be used during the research period, 17. Receive immunosuppressive therapy within 6 months before signing the informed consent form, such as long-term application of systemic glucocorticoid therapy (for more than 2 consecutive weeks in 6 months, application of systemic glucocorticoid therapy, such as prednisone or