Created at Source Raw Value Validated value
Dec. 4, 2021, midnight oms

[{"arm_notes": "", "treatment_id": null, "treatment_name": "This is a multicenter; randomized; double blinded; placebo controlled; Phase 3 clinicalefficacy study evaluating NONS in healthy adult volunteers as a prevention treatment forindividuals at risk from COVID-19 infection. The study settings include; National Institute of Infectious Diseases (IDH); Angoda; Colombo North Teaching Hospital; Ragama; Puttalam Base Hospital; Puttalam; Peradeniya Teaching Hospital; Peradeniya; Karapitiya Teaching Hospital; Galle; Negombo District General Hospital; Negombo Participants aged 18 or over with no known history of SARS-CoV-2 infection or previous vaccination against SARS-CoV-2 will be enrolled into one of two cohorts of this study in a ratio of 1:1 (Treatment: Placebo Control). Participants with or without underlying medical conditions will be eligible to enrol.Participants will self-administer a nasal spray three (3) times per day; morning; noon; and night containing either blinded study treatment or placebo (herein called study treatment). With the support of healthcare professionals in identified MoH divisions; site teams will be contacting eligible individuals for voluntary participation. Nitric oxide nasal spray will be delivered from manual pump nasal spray bottle containing25 mL of solution with each nasal spray dispensing approximately 130-150 microliters of solution. Each treatment will require two sprays per nostril (1 spray per nostril; repeated once); or about 0.56 mL per treatment (4 sprays total per dose).The NONS formulation proposed for use in this COVID- 19 clinical study will be self-administered at a maximum of 3 times per day; morning; noon; and night for 28 days. Sodium chloride will be used as the placebo for this trial. A sodium chloride wash is a known produ", "treatment_type": "TODO", "pharmacological_treatment": "TODO"}]

[{"arm_notes": "", "treatment_id": 1890, "treatment_name": "Nitric oxide nasal spray", "treatment_type": "Nasal spray", "pharmacological_treatment": "Non pharmacological treatment"}, {"arm_notes": "", "treatment_id": 2187, "treatment_name": "Placebo", "treatment_type": "Placebo", "pharmacological_treatment": "Placebo"}]