1. Subjects aged 18 ~ 59 who can provide legal identity certificates, both male and female, 2. The subjects understand the contents of the informed consent form and the vaccination, voluntarily sign the informed consent form, and have the ability to use the thermometer, scale and fill in the diary card and contact card as required, 3. Be able to communicate well with researchers, understand and abide by the requirements of this study, 4. For female subjects: no possibility of fertility (including amenorrhea for at least 1 year or surgical sterilization with medical records) or negative pregnancy test before inclusion in this study, The subjects voluntarily agreed to continue to use effective contraceptives with their partners within 3 months after completing the vaccination. Effective contraceptive measures include abstinence or adequate contraceptive measures [such as intrauterine or implantable contraceptive devices, oral contraceptives, injection or embedded contraception, slow-release local contraceptives, condoms (male), diaphragm, cervical cap, etc.), 5. Healthy subjects or subjects with mild basic diseases [at least 3 months before being selected for this study, they were in a stable state without aggravation (no hospitalization or major adjustment of treatment plan, etc.), 6. The second or third dose of the new coronavirus inactivated vaccine has been vaccinated for more than 6 months before enrollment. The interval between the first and second doses of novel coronavirus inactivated vaccine is 21 to 56 days, and the interval between the second and third doses of novel coronavirus inactivated vaccine is not less than 6 months.

1. Subjects aged 18 ~ 59 who can provide legal identity certificates, both male and female, 2. The subjects understand the contents of the informed consent form and the vaccination, voluntarily sign the informed consent form, and have the ability to use the thermometer, scale and fill in the diary card and contact card as required, 3. Be able to communicate well with researchers, understand and abide by the requirements of this study, 4. For female subjects: no possibility of fertility (including amenorrhea for at least 1 year or surgical sterilization with medical records) or negative pregnancy test before inclusion in this study, The subjects voluntarily agreed to continue to use effective contraceptives with their partners within 3 months after completing the vaccination. Effective contraceptive measures include abstinence or adequate contraceptive measures [such as intrauterine or implantable contraceptive devices, oral contraceptives, injection or embedded contraception, slow-release local contraceptives, condoms (male), diaphragm, cervical cap, etc.), 5. Healthy subjects or subjects with mild basic diseases [at least 3 months before being selected for this study, they were in a stable state without aggravation (no hospitalization or major adjustment of treatment plan, etc.), 6. The second or third dose of the new coronavirus inactivated vaccine has been vaccinated for more than 6 months before enrollment. The interval between the first and second doses of novel coronavirus inactivated vaccine is 21 to 56 days, and the interval between the second and third doses of novel coronavirus inactivated vaccine is not less than 6 months.

1. Subjects aged 18 ~ 59 who can provide legal identity certificates, both male and female, 2. The subjects understand the contents of the informed consent form and the vaccination, voluntarily sign the informed consent form, and have the ability to use the thermometer, scale and fill in the diary card and contact card as required, 3. Be able to communicate well with researchers, understand and abide by the requirements of this study, 4. For female subjects: no possibility of fertility (including amenorrhea for at least 1 year or surgical sterilization with medical records) or negative pregnancy test before inclusion in this study, The subjects voluntarily agreed to continue to use effective contraceptives with their partners within 3 months after completing the vaccination. Effective contraceptive measures include abstinence or adequate contraceptive measures [such as intrauterine or implantable contraceptive devices, oral contraceptives, injection or embedded contraception, slow-release local contraceptives, condoms (male), diaphragm, cervical cap, etc.), 5. Healthy subjects or subjects with mild basic diseases [at least 3 months before being selected for this study, they were in a stable state without aggravation (no hospitalization or major adjustment of treatment plan, etc.), 6. Before inoculation, 2 doses of New Coronavirus inactivated vaccine had been inoculated for 6 months or more, and the interval of 2 doses of new crown inactivated vaccine was 21~56 days.

1. Subjects aged 18 ~ 59 who can provide legal identity certificates, both male and female, 2. The subjects understand the contents of the informed consent form and the vaccination, voluntarily sign the informed consent form, and have the ability to use the thermometer, scale and fill in the diary card and contact card as required, 3. Be able to communicate well with researchers, understand and abide by the requirements of this study, 4. For female subjects: no possibility of fertility (including amenorrhea for at least 1 year or surgical sterilization with medical records) or negative pregnancy test before inclusion in this study, The subjects voluntarily agreed to continue to use effective contraceptives with their partners within 3 months after completing the vaccination. Effective contraceptive measures include abstinence or adequate contraceptive measures [such as intrauterine or implantable contraceptive devices, oral contraceptives, injection or embedded contraception, slow-release local contraceptives, condoms (male), diaphragm, cervical cap, etc.), 5. Healthy subjects or subjects with mild basic diseases [at least 3 months before being selected for this study, they were in a stable state without aggravation (no hospitalization or major adjustment of treatment plan, etc.), 6. Before inoculation, 2 doses of New Coronavirus inactivated vaccine had been inoculated for 6 months or more, and the interval of 2 doses of new crown inactivated vaccine was 21~56 days.