1. Participant or their legal representative is able and willing to provide informed consent 2. Symptoms attributable to COVID-19 started within the past 5 days and ongoing 3. A positive PCR SARS-CoV-2 test within the past 7 days 4. Aged =50 years OR aged 18-49 years with any known underlying chronic health condition considered to make them clinically vulnerable: 4.1. chronic respiratory disease (including chronic obstructive pulmonary disease (COPD), cystic fibrosis and asthma requiring at least daily use of preventative and/or reliever medication) 4.2. chronic heart or vascular disease 4.3. chronic kidney disease 4.4. chronic liver disease 4.5. chronic neurological disease (including dementia, stroke, epilepsy) 4.6. severe and profound learning disability 4.7. Down’s syndrome 4.8. diabetes mellitus (Type or Type II) 4.9. immunosuppression due to disease or treatment (e.g., sickle cell, HIV, cancer, chemotherapy) 4.10. solid organ, bone marrow and stem cell transplant recipients 4.11. morbid obesity (BMI >35) 4.12. severe mental illness 4.13. care home resident 4.14. judged by recruiting clinician or research nurse (registered medical practitioner or trained study nurse) to be clinically vulnerable

1. Participant or their legal representative is able and willing to provide informed consent 2. Symptoms attributable to COVID-19 started within the past 5 days and ongoing 3. A positive PCR SARS-CoV-2 test within the past 7 days 4. Aged =50 years OR aged 18-49 years with any known underlying chronic health condition considered to make them clinically vulnerable: 4.1. chronic respiratory disease (including chronic obstructive pulmonary disease (COPD), cystic fibrosis and asthma requiring at least daily use of preventative and/or reliever medication) 4.2. chronic heart or vascular disease 4.3. chronic kidney disease 4.4. chronic liver disease 4.5. chronic neurological disease (including dementia, stroke, epilepsy) 4.6. severe and profound learning disability 4.7. Down’s syndrome 4.8. diabetes mellitus (Type or Type II) 4.9. immunosuppression due to disease or treatment (e.g., sickle cell, HIV, cancer, chemotherapy) 4.10. solid organ, bone marrow and stem cell transplant recipients 4.11. morbid obesity (BMI >35) 4.12. severe mental illness 4.13. care home resident 4.14. judged by recruiting clinician or research nurse (registered medical practitioner or trained study nurse) to be clinically vulnerable