1. Patient currently admitted to hospital 2. Previous randomisation in the PANORAMIC trial 3. Currently participating in a clinical trial of a therapeutic agent for acute COVID-19 4. Participation in an investigational COVID-19 vaccine trial within previous 28 days 5. Additional exclusions specific to each intervention arm, if any, as listed in the Intervention Specific Appendices (ISA’s) of currently open trial arms

1. Patient currently admitted to hospital 2. Previous randomisation in the PANORAMIC trial 3. Currently participating in a clinical trial of a therapeutic agent for acute COVID-19 4. Participation in an investigational COVID-19 vaccine trial within previous 28 days 5. Additional exclusions specific to each intervention arm, if any, as listed in the Intervention Specific Appendices (ISA’s) of currently open trial arms