Created at Source Raw Value Validated value
Nov. 12, 2021, 5:03 p.m. oms

[{"arm_notes": "", "treatment_id": null, "treatment_name": "A platform trial; in contrast to say a traditional two-arm design; allows multiple arms to be considered simultaneously; and interventions can be dropped and replaced as evidence emerges for effectiveness or lack of it. The intent is to establish an on-going trial infrastructure within a master protocol that uses all the data already accumulated for the assessment of current and subsequently introduced interventions. New interventions will only be added after submission to the appropriate approval bodies. The trial will initially be two arms comparing usual care to usual care + Anti viral agent (name hidden for blinding) treatment. four 200mg tablets (800mg) will be taken by participants ever 12 hours (twice a day) for five days. This produce is licensed for emergency use in the UK (i.e. under trial circumstances). Randomisation: Participants will be randomised using a secure; fully validated and compliant web-based randomisation system. Once deemed eligible; the medically qualified clinician or research nurse from the central clinical team or Hub (as documented on the delegation log) will randomise the participant. Participants will be randomised to one study arm using equal allocation ratios corresponding to the number of eligible arms in the trial. For instance; if there are two active interventions (A & B); the allocation ratio will be 1:1:1 for Usual Care; active A; active B (respectively); such that 33% of participants are randomised to Usual Care. If there are 3 active interventions; the allocation ratio will be 1:1:1:1; such that 25% of participants are randomised to Usual Care. Patients must be eligible for at least two arms (Usual Care and at least one novel antiviral intervention). Stratificat", "treatment_type": "TODO", "pharmacological_treatment": "TODO"}]

[{"arm_notes": "", "treatment_id": 813, "treatment_name": "Molnupiravir", "treatment_type": "Antivirals", "pharmacological_treatment": "Pharmacological treatment"}, {"arm_notes": "", "treatment_id": 2188, "treatment_name": "Standard of care", "treatment_type": "Standard of care", "pharmacological_treatment": "Standard of care"}]