1. COVID-19 patients with age more than 15 year 2. Diagnosed as severe or critical COVID-19 infection 3. Already received favipirair or remdesivir in combination with corticosteroid (more than 6 mg of dexamethasone or equivalent dose) for more than 24-48 hours 4. Hyperinflammatory state including CRP &gt, 75 mg/L , ferritin &gt, 300 ng/ml and serum IL-6 level &gt, 20 pg/ml 5. Hypoxemia with PaO2 / FiO2 &lt, 300 and/or oxygen saturation room air &lt, 92 percent and/or Lung infiltration increasing more than 50 percent within 24-48 hours

1. COVID-19 patients with age more than 15 year 2. Diagnosed as severe or critical COVID-19 infection 3. Already received favipirair or remdesivir in combination with corticosteroid (more than 6 mg of dexamethasone or equivalent dose) for more than 24-48 hours 4. Hyperinflammatory state including CRP &gt, 75 mg/L , ferritin &gt, 300 ng/ml and serum IL-6 level &gt, 20 pg/ml 5. Hypoxemia with PaO2 / FiO2 &lt, 300 and/or oxygen saturation room air &lt, 92 percent and/or Lung infiltration increasing more than 50 percent within 24-48 hours