1. Patients in terminal states (estimated no more than 24 hours alive) 2. Pregnancy 3. History of HA-330 catridge or Tocilizumab allergy 4. Recent myocardial infarction within 1 month 5. Persistent shock more than 12 hours 6. Patients who accepted DNR (do not resuscitation)

1. Patients in terminal states (estimated no more than 24 hours alive) 2. Pregnancy 3. History of HA-330 catridge or Tocilizumab allergy 4. Recent myocardial infarction within 1 month 5. Persistent shock more than 12 hours 6. Patients who accepted DNR (do not resuscitation)