1. Female participants who are confirmed or suspected pregnant, planned to be pregnant within 90 days of the last vaccination, or lactating.2. Participants who are judged inappropriate in their health condition by Principal investigator or Sub-investigator.3. Participants who have known history of COVID-19.4. Participants who have history of COVID-19 vaccination, including investigational vaccine (exclusion placebo).5. Participants who have history of significant diseases of cardiac, vascular system (including thrombosis), blood, respiratory, hepatic, renal, GI, psychiatric diseases or disorders.6. Participants who have history of allergy such as systemic skin rash.7. Participants who have history of convulsion (including febrile convulsions), Guillain-Barre syndrome, acute disseminated encephalomyelitis.8. Participants who were diagnosed immune system disorder.9. Participants who are receiving or scheduling any medicine and/or therapy that could interfere with immunogenicity assessment of test medications.10. Participants who have history of anaphylaxis caused by food or medicines.11. Participants who have history or risk of allergy or anaphylaxis caused by any components of study medications.12. Participants who received any investigational product or vaccine 28 days prior to screening of this study, or who are planning to join any other investigation study during this study.13. Participants who are bleeding tendency and considered a contraindication to intramuscular injection by Principal investigator or Sub-investigator.14. Participants who received investigational product or medicine that contains lipid nano particle.

1. Female participants who are confirmed or suspected pregnant, planned to be pregnant within 90 days of the last vaccination, or lactating.2. Participants who are judged inappropriate in their health condition by Principal investigator or Sub-investigator.3. Participants who have known history of COVID-19.4. Participants who have history of COVID-19 vaccination, including investigational vaccine (exclusion placebo).5. Participants who have history of significant diseases of cardiac, vascular system (including thrombosis), blood, respiratory, hepatic, renal, GI, psychiatric diseases or disorders.6. Participants who have history of allergy such as systemic skin rash.7. Participants who have history of convulsion (including febrile convulsions), Guillain-Barre syndrome, acute disseminated encephalomyelitis.8. Participants who were diagnosed immune system disorder.9. Participants who are receiving or scheduling any medicine and/or therapy that could interfere with immunogenicity assessment of test medications.10. Participants who have history of anaphylaxis caused by food or medicines.11. Participants who have history or risk of allergy or anaphylaxis caused by any components of study medications.12. Participants who received any investigational product or vaccine 28 days prior to screening of this study, or who are planning to join any other investigation study during this study.13. Participants who are bleeding tendency and considered a contraindication to intramuscular injection by Principal investigator or Sub-investigator.14. Participants who received investigational product or medicine that contains lipid nano particle.