1. Have history of severe drug or vaccine allergy (anaphylaxis)?, 2. Have ever been detected COVID-19 infection?, 3.Have any history of contacting COVID-19 patient (high risk contact)?, 4. Positive result of antigen test kit?, 5. Have received blood transfusion, plasma, blood product, blood component, immunoglobulins, antiviral or antibodies within the last 90 days?, 6.Have history of cigarettes smoking, alcohol drinking and history of drug abuse? , 7. Being pregnant?, 8. Have unstable disease or could not control the symptom?, 9. Have history of immunodeficiency or been using immunosuppressant or steroid drugs?, 10. Have any unusual symptoms or medical history that considered unable to participate in the study?

1. Have history of severe drug or vaccine allergy (anaphylaxis)?, 2. Have ever been detected COVID-19 infection?, 3.Have any history of contacting COVID-19 patient (high risk contact)?, 4. Positive result of antigen test kit?, 5. Have received blood transfusion, plasma, blood product, blood component, immunoglobulins, antiviral or antibodies within the last 90 days?, 6.Have history of cigarettes smoking, alcohol drinking and history of drug abuse? , 7. Being pregnant?, 8. Have unstable disease or could not control the symptom?, 9. Have history of immunodeficiency or been using immunosuppressant or steroid drugs?, 10. Have any unusual symptoms or medical history that considered unable to participate in the study?