1. Have history of severe drug or vaccine allergy (anaphylaxis)? 2. Have detected COVID-19 infection? 3. Have history of COVID-19 high risk contact? 4. Have history of Chronic respiratory disease, CVD, CKD, CVS, obesity, cancer and DM? 5. Positive result(s) from either antigen test kit. 6. Have received blood transfusion, plasma, blood product, blood component, immunoglobilins, antiviral or antibodies within the last 90 days? 7. Have history of cigarettes smoking, alcohol drinking and history of drug abuse? 8. Being pregnant? 9. have unstable disease or could not control the sysptom? 10. Have history of immunodeficiency or been using immunosuppressant or steriod drugs? 11. Have any unusual symptoms or medical history that considered unable to participate in the study?

1. Have history of severe drug or vaccine allergy (anaphylaxis)? 2. Have detected COVID-19 infection? 3. Have history of COVID-19 high risk contact? 4. Have history of Chronic respiratory disease, CVD, CKD, CVS, obesity, cancer and DM? 5. Positive result(s) from either antigen test kit. 6. Have received blood transfusion, plasma, blood product, blood component, immunoglobilins, antiviral or antibodies within the last 90 days? 7. Have history of cigarettes smoking, alcohol drinking and history of drug abuse? 8. Being pregnant? 9. have unstable disease or could not control the sysptom? 10. Have history of immunodeficiency or been using immunosuppressant or steriod drugs? 11. Have any unusual symptoms or medical history that considered unable to participate in the study?

1. Have history of severe drug or vaccine allergy (anaphylaxis)? 2. Have detected COVID-19 infection? 3. Have history of COVID-19 high risj contact? 4. Have history of Chronic respiratory disease, CVD, CKD, CVS, obesity, cancer and DM? 5. Positive result(s) from either antigen test kit. 6. Have received blood transfusion, plasma, blood product, blood component, immunoglobilins, antiviral or antibodies within the last 90 days? 7. Have history of cigarettes smoking, alcohol drinking and history of drug abuse? 8. Being pregnant? 9. have unstable disease or could not control the sysptom? 10. Have history of immunodeficiency or been using immunosuppressant or steriod drugs? 11. Have any unusual symptoms or medical history that considered unable to participate in the study?

1. Have history of severe drug or vaccine allergy (anaphylaxis)? 2. Have detected COVID-19 infection? 3. Have history of COVID-19 high risj contact? 4. Have history of Chronic respiratory disease, CVD, CKD, CVS, obesity, cancer and DM? 5. Positive result(s) from either antigen test kit. 6. Have received blood transfusion, plasma, blood product, blood component, immunoglobilins, antiviral or antibodies within the last 90 days? 7. Have history of cigarettes smoking, alcohol drinking and history of drug abuse? 8. Being pregnant? 9. have unstable disease or could not control the sysptom? 10. Have history of immunodeficiency or been using immunosuppressant or steriod drugs? 11. Have any unusual symptoms or medical history that considered unable to participate in the study?