Acceptable symptom status of the patient. (Days to reach a state of acceptable symptoms; determined as the number of days that elapsed from the start of treatment until the patient answered with a Yes to the following question: Considering all the different ways your disease is affecting you; if you were to stay in this state for the next few months; do you consider that your current state is satisfactory? ”: Yes or No.) Measurement time: Daily; from patient randomization (baseline) to day 20.

Acceptable symptom status of the patient. (Days to reach a state of acceptable symptoms; determined as the number of days that elapsed from the start of treatment until the patient answered with a Yes to the following question: Considering all the different ways your disease is affecting you; if you were to stay in this state for the next few months; do you consider that your current state is satisfactory? ”: Yes or No.) Measurement time: Daily; from patient randomization (baseline) to day 20.