1. Male and female, age 18-55 years, inclusive. 2. Non-smoker or smokes on average less than or equal to 10 cigarettes per week 3. Woman participants must be non-pregnant and either surgically sterile, use an acceptable contraceptive method, or be post-menopausal 4. Male participants must be surgically sterile, abstinent, or if engaged in sexual relations with a WOCBP, the partner must be surgically sterile or using an acceptable contraceptive method 5. Negative SARS-CoV-2 RT-PCR nasal swab during screening period

1. Male and female, age 18-55 years, inclusive. 2. Non-smoker or smokes on average less than or equal to 10 cigarettes per week 3. Woman participants must be non-pregnant and either surgically sterile, use an acceptable contraceptive method, or be post-menopausal 4. Male participants must be surgically sterile, abstinent, or if engaged in sexual relations with a WOCBP, the partner must be surgically sterile or using an acceptable contraceptive method 5. Negative SARS-CoV-2 RT-PCR nasal swab during screening period