* age \< 18 y/o * patients currently receiving intravenous immunoglobulin * hypercoagulable state - neoplasia, collagen vascular disease, myelodysplastic syndrome, chronic anticoagulation treatment, etc. * need to be hospitalized * o2 sat \< 93% * d-dimer \> 2x normal * chronic oxygen therapy * renal insufficiency with creatinine clearance \< 30 * long term care or assisted living facility resident * ongoing usage of hydroxychloroquine for any indication * history of blood or plasma transfusion related complications * enrollment into any other investigational drug or device study within the previous 30 days * any drug, chemical or alcohol dependency as determined by the investigator through history that may affect study procedures and follow up * pregnant or breast feeding * any acute or chronic medical comorbidity, psychiatric, social or other circumstance that, in the opinion of the investigator, may interfere with study compliance, completion, or accurate assessment of the study outcomes/safety * admitted to or expected to be admitted to a medical facility

* age \< 18 y/o * patients currently receiving intravenous immunoglobulin * hypercoagulable state - neoplasia, collagen vascular disease, myelodysplastic syndrome, chronic anticoagulation treatment, etc. * need to be hospitalized * o2 sat \< 93% * d-dimer \> 2x normal * chronic oxygen therapy * renal insufficiency with creatinine clearance \< 30 * long term care or assisted living facility resident * ongoing usage of hydroxychloroquine for any indication * history of blood or plasma transfusion related complications * enrollment into any other investigational drug or device study within the previous 30 days * any drug, chemical or alcohol dependency as determined by the investigator through history that may affect study procedures and follow up * pregnant or breast feeding * any acute or chronic medical comorbidity, psychiatric, social or other circumstance that, in the opinion of the investigator, may interfere with study compliance, completion, or accurate assessment of the study outcomes/safety * admitted to or expected to be admitted to a medical facility

- age < 18 y/o - patients currently receiving intravenous immunoglobulin - hypercoagulable state - neoplasia, collagen vascular disease, myelodysplastic syndrome, chronic anticoagulation treatment, etc. - need to be hospitalized - o2 sat < 93% - d-dimer > 2x normal - chronic oxygen therapy - renal insufficiency with creatinine clearance < 30 - long term care or assisted living facility resident - ongoing usage of hydroxychloroquine for any indication - history of blood or plasma transfusion related complications - enrollment into any other investigational drug or device study within the previous 30 days - any drug, chemical or alcohol dependency as determined by the investigator through history that may affect study procedures and follow up - pregnant or breast feeding - any acute or chronic medical comorbidity, psychiatric, social or other circumstance that, in the opinion of the investigator, may interfere with study compliance, completion, or accurate assessment of the study outcomes/safety - admitted to or expected to be admitted to a medical facility

- age < 18 y/o - patients currently receiving intravenous immunoglobulin - hypercoagulable state - neoplasia, collagen vascular disease, myelodysplastic syndrome, chronic anticoagulation treatment, etc. - need to be hospitalized - o2 sat < 93% - d-dimer > 2x normal - chronic oxygen therapy - renal insufficiency with creatinine clearance < 30 - long term care or assisted living facility resident - ongoing usage of hydroxychloroquine for any indication - history of blood or plasma transfusion related complications - enrollment into any other investigational drug or device study within the previous 30 days - any drug, chemical or alcohol dependency as determined by the investigator through history that may affect study procedures and follow up - pregnant or breast feeding - any acute or chronic medical comorbidity, psychiatric, social or other circumstance that, in the opinion of the investigator, may interfere with study compliance, completion, or accurate assessment of the study outcomes/safety - admitted to or expected to be admitted to a medical facility