inclusion criteria: 1. males and females within the age range from 18 to 60 years; 2. written informed consent; 3. subject body mass index (bmi): 18.5 ≤ bmi ≤ 30; 4. negative pcr test results for sars-cov-2 (during the screening); 5. no history of covid-2019 disease; 6. no contacts of volunteers with patients with covid-2019 for at least 14 days; 7. negative test results for igm and igg antibodies to sars-cov-2; 8. subject agrees to use effective contraceptive methods during the entire period of participation in the study; 9. absence of acute infectious diseases at the time of vaccine administration and 14 days before vaccination; 10. negative pregnancy test of blood or urine (for women of childbearing age); 11. subject has negative tests for hiv, hepatitis b and с, syphilis or confirmed medical history; 12. subject has a negative result of the urine test for residual narcotic drugs; 13. negative test for alcohol in exhaled air; 14. the absence of malignant diseases of any nature and localization; 15. in medical history and based on the screening results, subject has no diseases or pathologies of the gastrointestinal system, liver, kidneys, cardiovascular system and blood, cns, musculoskeletal system, urogenital, immune and endocrine systems that from the point of view of the researcher and/or of the organizer of the study, may affect the safety of the volunteer and the evaluation of the study results (clinical, instrumental and laboratory tests did not reveal diseases or clinically significant deviations).

inclusion criteria: 1. males and females within the age range from 18 to 60 years; 2. written informed consent; 3. subject body mass index (bmi): 18.5 ≤ bmi ≤ 30; 4. negative pcr test results for sars-cov-2 (during the screening); 5. no history of covid-2019 disease; 6. no contacts of volunteers with patients with covid-2019 for at least 14 days; 7. negative test results for igm and igg antibodies to sars-cov-2; 8. subject agrees to use effective contraceptive methods during the entire period of participation in the study; 9. absence of acute infectious diseases at the time of vaccine administration and 14 days before vaccination; 10. negative pregnancy test of blood or urine (for women of childbearing age); 11. subject has negative tests for hiv, hepatitis b and с, syphilis or confirmed medical history; 12. subject has a negative result of the urine test for residual narcotic drugs; 13. negative test for alcohol in exhaled air; 14. the absence of malignant diseases of any nature and localization; 15. in medical history and based on the screening results, subject has no diseases or pathologies of the gastrointestinal system, liver, kidneys, cardiovascular system and blood, cns, musculoskeletal system, urogenital, immune and endocrine systems that from the point of view of the researcher and/or of the organizer of the study, may affect the safety of the volunteer and the evaluation of the study results (clinical, instrumental and laboratory tests did not reveal diseases or clinically significant deviations).

inclusion criteria: males and females within the age range from 18 to 60 years; written informed consent; subject body mass index (bmi): 18.5 ≤ bmi ≤ 30; negative pcr test results for sars-cov-2 (during the screening); no history of covid-2019 disease; no contacts of volunteers with patients with covid-2019 for at least 14 days; negative test results for igm and igg antibodies to sars-cov-2; subject agrees to use effective contraceptive methods during the entire period of participation in the study; absence of acute infectious diseases at the time of vaccine administration and 14 days before vaccination; negative pregnancy test of blood or urine (for women of childbearing age); subject has negative tests for hiv, hepatitis b and с, syphilis or confirmed medical history; subject has a negative result of the urine test for residual narcotic drugs; negative test for alcohol in exhaled air; the absence of malignant diseases of any nature and localization; in medical history and based on the screening results, subject has no diseases or pathologies of the gastrointestinal system, liver, kidneys, cardiovascular system and blood, cns, musculoskeletal system, urogenital, immune and endocrine systems that from the point of view of the researcher and/or of the organizer of the study, may affect the safety of the volunteer and the evaluation of the study results (clinical, instrumental and laboratory tests did not reveal diseases or clinically significant deviations).

inclusion criteria: males and females within the age range from 18 to 60 years; written informed consent; subject body mass index (bmi): 18.5 ≤ bmi ≤ 30; negative pcr test results for sars-cov-2 (during the screening); no history of covid-2019 disease; no contacts of volunteers with patients with covid-2019 for at least 14 days; negative test results for igm and igg antibodies to sars-cov-2; subject agrees to use effective contraceptive methods during the entire period of participation in the study; absence of acute infectious diseases at the time of vaccine administration and 14 days before vaccination; negative pregnancy test of blood or urine (for women of childbearing age); subject has negative tests for hiv, hepatitis b and с, syphilis or confirmed medical history; subject has a negative result of the urine test for residual narcotic drugs; negative test for alcohol in exhaled air; the absence of malignant diseases of any nature and localization; in medical history and based on the screening results, subject has no diseases or pathologies of the gastrointestinal system, liver, kidneys, cardiovascular system and blood, cns, musculoskeletal system, urogenital, immune and endocrine systems that from the point of view of the researcher and/or of the organizer of the study, may affect the safety of the volunteer and the evaluation of the study results (clinical, instrumental and laboratory tests did not reveal diseases or clinically significant deviations).

inclusion criteria: 1. males and females within the age range from 18 to 60 years; 2. written informed consent; 3. subject body mass index (bmi): 18.5 ≤ bmi ≤ 30; 4. negative pcr test results for sars-cov-2 (during the screening); 5. no history of covid-2019 disease; 6. no contacts of volunteers with patients with covid-2019 for at least 14 days; 7. negative test results for igm and igg antibodies to sars-cov-2; 8. subject agrees to use effective contraceptive methods during the entire period of participation in the study; 9. absence of acute infectious diseases at the time of vaccine administration and 14 days before vaccination; 10. negative pregnancy test of blood or urine (for women of childbearing age); 11. subject has negative tests for hiv, hepatitis b and с, syphilis or confirmed medical history; 12. subject has a negative result of the urine test for residual narcotic drugs; 13. negative test for alcohol in exhaled air; 14. the absence of malignant diseases of any nature and localization; 15. in medical history and based on the screening results, subject has no diseases or pathologies of the gastrointestinal system, liver, kidneys, cardiovascular system and blood, cns, musculoskeletal system, urogenital, immune and endocrine systems that from the point of view of the researcher and/or of the organizer of the study, may affect the safety of the volunteer and the evaluation of the study results (clinical, instrumental and laboratory tests did not reveal diseases or clinically significant deviations).

inclusion criteria: 1. males and females within the age range from 18 to 60 years; 2. written informed consent; 3. subject body mass index (bmi): 18.5 ≤ bmi ≤ 30; 4. negative pcr test results for sars-cov-2 (during the screening); 5. no history of covid-2019 disease; 6. no contacts of volunteers with patients with covid-2019 for at least 14 days; 7. negative test results for igm and igg antibodies to sars-cov-2; 8. subject agrees to use effective contraceptive methods during the entire period of participation in the study; 9. absence of acute infectious diseases at the time of vaccine administration and 14 days before vaccination; 10. negative pregnancy test of blood or urine (for women of childbearing age); 11. subject has negative tests for hiv, hepatitis b and с, syphilis or confirmed medical history; 12. subject has a negative result of the urine test for residual narcotic drugs; 13. negative test for alcohol in exhaled air; 14. the absence of malignant diseases of any nature and localization; 15. in medical history and based on the screening results, subject has no diseases or pathologies of the gastrointestinal system, liver, kidneys, cardiovascular system and blood, cns, musculoskeletal system, urogenital, immune and endocrine systems that from the point of view of the researcher and/or of the organizer of the study, may affect the safety of the volunteer and the evaluation of the study results (clinical, instrumental and laboratory tests did not reveal diseases or clinically significant deviations).