* pregnant or breast feeding * mews \>=3 * hepatic failure child-pugh c * enrollment in other pharmacological studies * ongoing treatment with colchicine * ongoing treatment with antiviral drugs that include ritonavir or cobicistat * any medical condition or disease which in the opinion of the investigator may place the patient at unacceptable risk for study participation.

* pregnant or breast feeding * mews \>=3 * hepatic failure child-pugh c * enrollment in other pharmacological studies * ongoing treatment with colchicine * ongoing treatment with antiviral drugs that include ritonavir or cobicistat * any medical condition or disease which in the opinion of the investigator may place the patient at unacceptable risk for study participation.

- pregnant or breast feeding - mews >=3 - hepatic failure child-pugh c - enrollment in other pharmacological studies - ongoing treatment with colchicine - ongoing treatment with antiviral drugs that include ritonavir or cobicistat - any medical condition or disease which in the opinion of the investigator may place the patient at unacceptable risk for study participation.

- pregnant or breast feeding - mews >=3 - hepatic failure child-pugh c - enrollment in other pharmacological studies - ongoing treatment with colchicine - ongoing treatment with antiviral drugs that include ritonavir or cobicistat - any medical condition or disease which in the opinion of the investigator may place the patient at unacceptable risk for study participation.